Outcomes of Postchemotherapy Retroperitoneal Lymph Node Dissection from a High-volume UK Centre Compared with a National Data Set

Autor: David Manson-Bahr, Alison Reid, Adam Pearce, Erik Mayer, Robert Huddart, David Nicol
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: European Urology Open Science, Vol 33, Iss, Pp 83-88 (2021)
European Urology Open Science
ISSN: 2666-1683
Popis: Background Retroperitoneal lymph node dissection (RPLND) is essential for the treatment of metastatic germ cell tumours of the testis. Recommendations on the referral and management of complex urological cancers in the UK includes centralisation of services to regional centres. Objective To review contemporary PC-RPLND outcomes at a high-volume centre with a complex case-mix, and compare with national registry data. Design, setting, and participants We retrospectively reviewed the medical records of PC-RPLNDs performed for germ cell tumours at our centre between July 2012 and September 2018. Outcome measurements and statistical analysis Primary outcomes were Clavien 3+ complications, histology, rates of positive margin, relapse, in-field recurrences, and mortality. Secondary outcomes were blood loss, operation time, blood transfusion, adjuvant procedures, length of stay, and lymph node count. Surgical and histological outcomes of all RPLNDs for testicular cancers were compared with national RPLND registry data. For statistical difference, χ2 testing was used. Results and limitations A total of 178 procedures were performed, including 31 (17%) redo RPLNDs. Clavien 3+ complications occurred in 11 (7%). Histological findings in non-redo cases were the following: necrosis 24%, teratoma 62%, viable germ cell tumour 11%, and dedifferentiated cancers 3%. Rates of positive margin, relapse, and in-field recurrence were 11%, 17%, and 2%, respectively. Overall survival was 89% at a median of 36 mo. The median blood loss was 650 ml (350, 1250), with a transfusion rate of 8%. Nephrectomy, vascular reconstruction, and visceral resection was required in 12%, 6%, and 3% respectively. The median inpatient stay was 6 d (5, 8) and the median node count was 35 (20, 37). A comparison of all RPLNDs with national data showed no statistical difference in primary outcomes. Our blood transfusion rate was significantly lower (12% vs 21%, χ2 [1, N = 322] = 4.296, p = 0.038). Conclusions Centralisation led to high quality of RPLND in UK. Within that, our series (the largest in the UK) demonstrates no significant difference in outcomes despite higher complexity cases. Our blood transfusion rates are in fact lower than national figures. Complex RPLNDs should be performed in high-volume centres where possible. Patient summary In the UK, retroperitoneal lymph node dissections (RPLND) are centralised to specialist centres and the quality of surgery is high, with low complications and good histological outcomes. When compared to national data, we found no significant difference in the majority of outcomes from our high-volume centre despite our complex case-mix.
Take Home Message This is the largest postchemotherapy retroperitoneal lymph node dissection (RPLND) series in the UK. Centralisation has led to a high standard of RPLNDs nationally, lower proportion of RPLNDs performed for necrosis only, and the evolution of high-volume centres. The benefits of high volume centres are the following: no significant difference in the majority of outcomes despite the higher proportion of complex cases and a reduced blood transfusion rate; transfusion is linked to poorer oncological outcomes in a number of malignancies.
Databáze: OpenAIRE
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