DIP1 plays an antiviral role against DCV infection in Drosophila melanogaster
| Autor: | Liqin Zhang, Zhaoxia Chang, Xinlei Gao, Qi Zhang, Shuishui Qi, Qingfa Wu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Mutant
Biophysics Insect Viruses Biochemistry Cell Line In vivo Animals Drosophila Proteins DIP1 Molecular Biology Transcription factor Antiviral gene DNA Primers Innate immune system Base Sequence biology Schneider 2 cells fungi dsRNA binding domain DCV Cell Biology biology.organism_classification Virology Drosophila melanogaster Virus Diseases Cell culture Drosophila Protein Transcription Factors |
| Zdroj: | Biochemical and Biophysical Research Communications. 460:222-226 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2015.03.013 |
| Popis: | Disconnected Interacting Protein 1 (DIP1) is a dsRNA-binding protein that participates in a wide range of cellular processes. Whether DIP1 is involved in innate immunity remains unclear. Here, DIP1 was found to play an antiviral role in S2 cells. Its antiviral action is specific for DCV infection and not for DXV infection. dip1 mutant flies are hypersensitive to DCV infection. The increased mortality in dip1 mutant flies is associated with the accumulation of DCV positive-stranded RNAs in vivo. This study demonstrated that dip1 is a novel antiviral gene that restricts DCV replication in vitro and in vivo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect