Kisspeptin as a New Serum Biomarker to Discriminate Miscarriage from Viable Intrauterine Pregnancy
| Autor: | Chantae Sullivan-Pyke, Esther Eisenberg, Kurt T. Barnhart, Suneeta Senapati, Olivia Nicolais, Daniel J. Haisenleder, Mary D. Sammel |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Pregnancy Tests Gestational Age Abortion Chorionic Gonadotropin Intrauterine pregnancy Article Miscarriage Diagnosis Differential Young Adult 03 medical and health sciences 0302 clinical medicine Kisspeptin Limit of Detection Predictive Value of Tests Serum biomarkers Pregnancy medicine Humans Gynecology Kisspeptins 030219 obstetrics & reproductive medicine business.industry Obstetrics Reproducibility of Results Obstetrics and Gynecology Gestational age medicine.disease Abortion Spontaneous Pregnancy Trimester First ESTIMATED GESTATIONAL AGE Cross-Sectional Studies 030104 developmental biology Reproductive Medicine Case-Control Studies Biomarker (medicine) Female business hormones hormone substitutes and hormone antagonists Biomarkers |
| Popis: | Objective To validate the ability of serum kisspeptin-54 to discriminate between first-trimester viable pregnancies and miscarriages. Design Case-control study. Setting Academic medical centers. Patient(s) Women with confirmed viable intrauterine pregnancy (IUP) at estimated gestational age 6–10 weeks (n = 20), women with confirmed miscarriage (spontaneous abortion [SAB]) at estimated gestational age 6–10 weeks (n = 20), and nonpregnant women (n = 19). Intervention(s) Collection of serum samples from women with confirmed IUP, SAB, and nonpregnant women for the measurement of serum kisspeptin and serum hCG levels. Main Outcome Measure(s) Serum kisspeptin and hCG. Result(s) The limit of detection was 0.024 ng/mL; intra- and interassay coefficients of variation were 5.1% and 8.6%, respectively. Kisspeptin levels differed between the pregnant and nonpregnant state and by viability. Kisspeptin levels were positively associated with gestational age. There was also a significant positive association with hCG in SAB, but not in IUP. Conclusion(s) Plasma levels of kisspeptin have been suggested as a biomarker for miscarriage. This study demonstrates kisspeptin assay stability in serum and its potential clinical utility as a biomarker for early pregnancy viability. |
| Databáze: | OpenAIRE |
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