The Effects of Pleural Plaques on Longitudinal Lung Function in Vermiculite Miners of Libby, Montana
Autor: | Lawrence C. Mohr, J. Jay Flynn, Wilfried Karmaus, Kathleen A. Clark |
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Rok vydání: | 2016 |
Předmět: |
Male
medicine.medical_specialty Pathology Miners Vermiculite medicine.disease_cause Pleural thickening Gastroenterology Asbestos 03 medical and health sciences 0302 clinical medicine Internal medicine Diffusing capacity Occupational Exposure medicine Humans 030212 general & internal medicine Longitudinal Studies Lung Lung function Aged Retrospective Studies Montana business.industry Asbestos Amphibole General Medicine respiratory system Middle Aged Pleural Diseases 030210 environmental & occupational health respiratory tract diseases Respiratory Function Tests medicine.anatomical_structure Smoking status Aluminum Silicates business Tomography X-Ray Computed Body mass index |
Zdroj: | The American journal of the medical sciences. 353(6) |
ISSN: | 1538-2990 |
Popis: | This study was conducted to assess associations of pleural plaques (PP) and longitudinal lung function in vermiculite miners of Libby, Montana who are occupationally exposed to asbestos. High-resolution computed tomography (HRCT) was used to identify asbestos-related findings in former Libby vermiculite miners. We investigated annual lung function decline in miners with PP only and compared them to miners with normal HRCT findings.HRCTs from 128 miners were categorized into the following 4 diagnostic groups: (1) normal computed tomography scan (n = 9); (2) PP only (n = 72); (3) PP and interstitial fibrosis (n = 26) and (4) additional HRCT abnormalities (n = 21) such as rounded atelectasis, diffuse pleural thickening, pleural effusions or pulmonary nodules or tumor1cm in diameter. Random intercept and slope linear mixed-effect regression models identified differences in lung function decline between miners with asbestos-associated outcomes and those with normal HRCT. Models were adjusted for follow-up time, body mass index, smoking status, latent exposure period and employment years. Interactions for smoking status with age and smoking status with pleural plaque severity were examined.Miners with PP only did not have an accelerated decline in lung function between 40 and 80 years. Miners with PP and additional HRCT abnormalities displayed significantly accelerated declines in forced expiratory volume in 1 second and diffusing capacity of the lungs for carbon monoxide (P = 0.05 and P0.01, respectively). Plaque severity did not affect lung function decline. However, smokers with extensive plaques displayed accelerated loss in diffusing capacity of the lungs for carbon monoxide and forced expiratory volume in 1 second when compared to nonsmoking miners with mild plaque formation.PP alone did not significantly affect lung function decline in vermiculite miners of Libby, Montana. |
Databáze: | OpenAIRE |
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