Comparison of demographic and clinical characteristics of hospitalized COVID‐19 patients with severe/critical illness in the first wave versus the second wave

Autor: Muhammed Emin Kostek, Sinem Nihal Esatoglu, Elif Sargin Altunok, Semih Yazla, İlkim Deniz Toprak, Mustafa Asim Demirkol, Mustafa Alkan, Celal Satici, Sadettin Kamat, Veysel Dinc
Rok vydání: 2021
Předmět:
Male
Pediatrics
Turkey
Comorbidity
Azithromycin
demographic characteristics
Severity of Illness Index
Lopinavir
law.invention
the first versus second wave
Interquartile range
law
Hospital Mortality
Research Articles
Univariate analysis
Mortality rate
Middle Aged
Intensive care unit
Hospitalization
Drug Combinations
C-Reactive Protein
Treatment Outcome
Infectious Diseases
Pyrazines
Female
Hydroxychloroquine
Research Article
medicine.medical_specialty
Critical Care
Coronavirus disease 2019 (COVID-19)
Antibodies
Monoclonal
Humanized

Methylprednisolone
World health
COVID‐19
Virology
medicine
Humans
Enoxaparin
Aged
Retrospective Studies
Ritonavir
SARS-CoV-2
business.industry
COVID-19
medicine.disease
Amides
mortality
COVID-19 Drug Treatment
Interleukin 1 Receptor Antagonist Protein
Critical illness
business
Kidney disease
Zdroj: Journal of Medical Virology
ISSN: 1096-9071
0146-6615
DOI: 10.1002/jmv.27319
Popis: Due to current advances and growing experience in the management of coronavirus Disease 2019 (COVID‐19), the outcome of COVID‐19 patients with severe/critical illness would be expected to be better in the second wave compared with the first wave. As our hospitalization criteria changed in the second wave, we aimed to investigate whether a favorable outcome occurred in hospitalized COVID‐19 patients with only severe/critical illness. Among 642 laboratory‐confirmed hospitalized COVID‐19 patients in the first wave and 1121 in the second wave, those who met World Health Organization (WHO) definitions for severe or critical illness on admission or during follow‐up were surveyed. Data on demographics, comorbidities, C‐reactive protein (CRP) levels on admission, and outcomes were obtained from an electronic hospital database. Univariate analysis was performed to compare the characteristics of patients in the first and second waves. There were 228 (35.5%) patients with severe/critical illness in the first wave and 681 (60.7%) in the second wave. Both groups were similar in terms of age, gender, and comorbidities, other than chronic kidney disease. Median serum CRP levels were significantly higher in patients in the second wave compared with those in the first wave [109 mg/L (interquartile range [IQR]: 65–157) vs. 87 mg/L (IQR: 39–140); p
Highlights Even though a lower mortality rate in the second wave has been reported in previous studies, including all hospitalized COVID‐19 patients, we found similar AQ4demographics and outcomes among hospitalized COVID‐19 patients with severe/critical illness in the first and second wave.
Databáze: OpenAIRE