Comparison of demographic and clinical characteristics of hospitalized COVID‐19 patients with severe/critical illness in the first wave versus the second wave
Autor: | Muhammed Emin Kostek, Sinem Nihal Esatoglu, Elif Sargin Altunok, Semih Yazla, İlkim Deniz Toprak, Mustafa Asim Demirkol, Mustafa Alkan, Celal Satici, Sadettin Kamat, Veysel Dinc |
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Rok vydání: | 2021 |
Předmět: |
Male
Pediatrics Turkey Comorbidity Azithromycin demographic characteristics Severity of Illness Index Lopinavir law.invention the first versus second wave Interquartile range law Hospital Mortality Research Articles Univariate analysis Mortality rate Middle Aged Intensive care unit Hospitalization Drug Combinations C-Reactive Protein Treatment Outcome Infectious Diseases Pyrazines Female Hydroxychloroquine Research Article medicine.medical_specialty Critical Care Coronavirus disease 2019 (COVID-19) Antibodies Monoclonal Humanized Methylprednisolone World health COVID‐19 Virology medicine Humans Enoxaparin Aged Retrospective Studies Ritonavir SARS-CoV-2 business.industry COVID-19 medicine.disease Amides mortality COVID-19 Drug Treatment Interleukin 1 Receptor Antagonist Protein Critical illness business Kidney disease |
Zdroj: | Journal of Medical Virology |
ISSN: | 1096-9071 0146-6615 |
DOI: | 10.1002/jmv.27319 |
Popis: | Due to current advances and growing experience in the management of coronavirus Disease 2019 (COVID‐19), the outcome of COVID‐19 patients with severe/critical illness would be expected to be better in the second wave compared with the first wave. As our hospitalization criteria changed in the second wave, we aimed to investigate whether a favorable outcome occurred in hospitalized COVID‐19 patients with only severe/critical illness. Among 642 laboratory‐confirmed hospitalized COVID‐19 patients in the first wave and 1121 in the second wave, those who met World Health Organization (WHO) definitions for severe or critical illness on admission or during follow‐up were surveyed. Data on demographics, comorbidities, C‐reactive protein (CRP) levels on admission, and outcomes were obtained from an electronic hospital database. Univariate analysis was performed to compare the characteristics of patients in the first and second waves. There were 228 (35.5%) patients with severe/critical illness in the first wave and 681 (60.7%) in the second wave. Both groups were similar in terms of age, gender, and comorbidities, other than chronic kidney disease. Median serum CRP levels were significantly higher in patients in the second wave compared with those in the first wave [109 mg/L (interquartile range [IQR]: 65–157) vs. 87 mg/L (IQR: 39–140); p Highlights Even though a lower mortality rate in the second wave has been reported in previous studies, including all hospitalized COVID‐19 patients, we found similar AQ4demographics and outcomes among hospitalized COVID‐19 patients with severe/critical illness in the first and second wave. |
Databáze: | OpenAIRE |
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