Coagulation profile in patients undergoing video-assisted thoracoscopic lobectomy:A randomized, controlled trial

Autor: Kåre Hornbech, Anne-Mette Hvas, Henrik Vad, Thomas Christensen, S. Pedersen, Nora Elisabeth Zois, Mads Nybo, Peter B. Licht
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Lung Neoplasms
Cancer Treatment
Normal Distribution
lcsh:Medicine
030204 cardiovascular system & hematology
Biochemistry
Lung and Intrathoracic Tumors
law.invention
0302 clinical medicine
Randomized controlled trial
law
Clinical endpoint
Medicine and Health Sciences
Medicine
Postoperative Period
lcsh:Science
Lung cancer surgery
Multidisciplinary
medicine.diagnostic_test
biology
Thoracic Surgery
Video-Assisted
Thrombin
Drugs
Middle Aged
Thromboelastometry
Surgical Oncology
Oncology
030220 oncology & carcinogenesis
Physical Sciences
Female
Partial Thromboplastin Time
Research Article
Clinical Oncology
medicine.medical_specialty
VATS lobectomy
Surgical and Invasive Medical Procedures
Minimally Invasive Surgery
Fibrin
Fibrin Fibrinogen Degradation Products
03 medical and health sciences
Thromboembolism
Journal Article
Blood test
Humans
Lung cancer
Blood Coagulation
Aged
Pharmacology
Surgical Excision
business.industry
Heparin
lcsh:R
Biology and Life Sciences
Proteins
Cancers and Neoplasms
Anticoagulants
Fibrinogen
Heparin
Low-Molecular-Weight
medicine.disease
Probability Theory
Probability Distribution
Surgery
biology.protein
Lobectomy
lcsh:Q
Clinical Medicine
business
Mathematics
Zdroj: Christensen, T D, Vad, H, Pedersen, S, Hornbech, K, Zois, N E, Licht, P B, Nybo, M & Hvas, A-M 2017, ' Coagulation profile in patients undergoing video-assisted thoracoscopic lobectomy : A randomized, controlled trial ', PLoS ONE, vol. 12, no. 2, e0171809 . https://doi.org/10.1371/journal.pone.0171809
Christensen, T D, Vad, H, Pedersen, S, Hornbech, K, Zois, N E, Licht, P B, Nybo, M & Hvas, A-M 2017, ' Coagulation profile in patients undergoing video-assisted thoracoscopic lobectomy : A randomized, controlled trial ', PLOS ONE, vol. 12, no. 2, pp. e0171809 . https://doi.org/10.1371/journal.pone.0171809
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0171809 (2017)
DOI: 10.1371/journal.pone.0171809
Popis: Background: Knowledge about the impact of Low-Molecular-Weight Heparin (LMWH) on the coagulation system in patients undergoing minimal invasive lung cancer surgery is sparse. The aim of this study was to assess the effect of LMWH on the coagulation system in patients undergoing Video-Assisted Thoracoscopic Surgery (VATS) lobectomy for primary lung cancer. Methods: Sixty-three patients diagnosed with primary lung cancer undergoing VATS lobectomy were randomized to either subcutaneous injection with dalteparin (Fragmin®) 5000 IE once daily or no intervention. Coagulation was assessed pre-, peri-, and the first two days postoperatively by standard coagulation blood test, thromboelastometry (ROTEM®) and thrombin generation. Results: Patients undergoing potential curative surgery for lung cancer were not hypercoagulable preoperatively. There was no statistically significant difference in the majority of the assessed coagulation parameters after LMWH, except that the no intervention group had a higher peak thrombin and a shorter INTEM clotting time on the first postoperative day and a lower fibrinogen level on the second postoperative day. A lower level of fibrin d-dimer in the LMWH group was found on the 1. and 2.postoperative day, although not statistical significant. No differences were found between the two groups in the amount of bleeding or number of thromboembolic events. Conclusions: Use of LMWH administered once daily as thromboprophylaxis did not alter the coagulation profile per se. As the present study primarily evaluated biochemical endpoints, further studies using clinical endpoints are needed in regards of an optimized thromboprophylaxis approach.
Databáze: OpenAIRE
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