New method of creating hybrid of buprenorphine loaded rifampin/polyethylene glycol/alginate nanoparticles
| Autor: | Sara Masoumi, Akbar Esmaeili |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Drug
Alginates Narcotic Antagonists media_common.quotation_subject 02 engineering and technology Polyethylene glycol Pharmacology Ferric Compounds Biochemistry Polyethylene Glycols 03 medical and health sciences chemistry.chemical_compound Structural Biology In vivo medicine Animals Rats Wistar Molecular Biology 030304 developmental biology media_common 0303 health sciences biology Chemistry Cytochrome P450 General Medicine 021001 nanoscience & nanotechnology In vitro Anti-Bacterial Agents Buprenorphine Rats Drug Liberation Liver Drug delivery biology.protein Morphine Nanoparticles Rifampin Zinc Oxide 0210 nano-technology medicine.drug |
| Zdroj: | International Journal of Biological Macromolecules. 159:204-212 |
| ISSN: | 0141-8130 |
| Popis: | An indicator for cytochrome P450 enzymes which have the most fundamental role in methadone metabolism in the liver. In this study preparation in vitro, in vivo release and biological activities of Fe3O4@ZnO/rifampin/polyethylene glycol/buprenorphine/alginate nanoparticles investigated. Rifampin is activator for the cytochrome P-3 enzymes which can detoxify residual drugs in the liver. This paper examines the changes pH, absorption rate, drug release, in vivo test (30 rats) in selected Wistar rats. All rats were either orally addicted to morphine after 21 days. After establishing dependence based on an observation of behavioral parameters the ability to quit the new drug was evaluated. In vitro and in vitro tests on antibacterial activity and multiple intestinal inflammation in addicts were conducted. Recent drug delivery systems that use polymers cause more sustainability of drug in the body and also prevent drug interactions. This research showed the success of decreasing consumption dose of the drug from 0.004 to 0.0005 mg, increasing lifetime from 24 to 32 h to 72–96 h, and decreasing the number of hepatic tissues that were damaged. The results of this investigation were confirmed by clinical tests and the dyeing process of mason tri‑chromium and hematoxylin and eosin. |
| Databáze: | OpenAIRE |
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