Heightened Expression of Cyclooxygenase-2 and Peroxisome Proliferator-Activated Receptor-δ in Human Endometrial Adenocarcinoma
| Autor: | Sudhansu K. Dey, Lovella Tajeda, Julia Chapman, Raymond N. DuBois, Jian Tan, Sanjoy K. Das, Beverly J. Tong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Cancer Research
medicine.medical_specialty Peroxisome proliferator-activated receptor Prostaglandin Prostacyclin lcsh:RC254-282 prostaglandins chemistry.chemical_compound Internal medicine medicine human Receptor chemistry.chemical_classification biology uterus medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens cyclooxygenase Endocrinology Nuclear receptor chemistry endometrial cancer biology.protein Cancer research Adenocarcinoma Peroxisome proliferator-activated receptor delta Cyclooxygenase medicine.drug |
| Zdroj: | Neoplasia: An International Journal for Oncology Research, Vol 2, Iss 6, Pp 483-490 (2000) |
| ISSN: | 1522-8002 1476-5586 |
| Popis: | Epidemiological studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) significantly reduce the risk and mortality from colorectal cancer, in part by inhibiting prostaglandin (PG) synthesis. Cyclooxygenase (COX), the rate-limiting enzyme in PG biosynthesis, exists in two isoforms, COX-1 and COX-2. Genetic and pharmacological evidence suggest that COX-2 is involved in the development of colorectal cancer. We have previously shown that COX-2-derived prostacyclin participates in blastocyst implantation through activation of peroxisome proliferator activated receptor delta (PPARdelta), a member of the nuclear hormone receptor family. Furthermore, our recent studies suggest that a similar pathway is operative during colorectal carcinogenesis. These observations prompted us to examine whether the COX-2-PPARdelta signaling pathway is also involved during development of uterine adenocarcinoma. Here we describe for the first time the heightened expression of COX-2 and PPARdelta, but not COX-1, in uterine endometrial adenocarcinoma. |
| Databáze: | OpenAIRE |
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