Electron beam ionization mass fragmentographic analysis of tricyclic antidepressants in human plasma
| Autor: | William R. Sherman, Paul P. Hipps, William H. Holland, Sidney T. Chang, John T. Biggs |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
chemistry.chemical_classification
Adult Chromatography Chromatography Gas Time Factors Chemistry Pharmaceutical Science Protriptyline Antidepressive Agents Tricyclic Mass spectrometry Doxepin Imipramine Gas Chromatography-Mass Spectrometry Mass Spectrometry Desipramine medicine Humans Amitriptyline Nortriptyline medicine.drug Tricyclic |
| Zdroj: | Journal of pharmaceutical sciences. 65(2) |
| ISSN: | 0022-3549 |
| Popis: | A method for the measurement, in human plasma, of all tertiary and secondary tricyclic antidepressants prescribed in the United States is described. The method uses electron beam ionization GLC-mass spectrometry, employing a computer-controlled multiple-ion detector. This method, mass fragmentography, is used with internal standards for each drug. Plasma levels to as low as 10 ng/ml of the following drugs can be measured: amitriptyline, nortriptyline, doxepin, desmethyldoxepin, imipramine, desipramine, and protriptyline. Deuterium-labeled amitriptyline and imipramine are used as internal standards for those two drugs; for the other drugs, deuterated amitriptyline, nortriptyline, desmethyldoxepin, or desipramine is used. The method can measure up to 15 samples/hr, making it practical for large-scale studies of these drugs in patients. Spectra of each drug and examples of their analysis are given. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text