Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists

Autor:	Susan E. Bove, Christopher S. Knauer, Roy D. Schwarz, Rachel M. Brooker, John A. Wendt, Corinne E. Augelli-Szafran, Jack J. Kinsora, Susan D. Deeter, Kenneth S. Kilgore
Rok vydání:	2007
Předmět:	Pyrimidine Stereochemistry Pyridines Receptor Metabotropic Glutamate 5 Clinical Biochemistry Pharmaceutical Science CHO Cells Receptors Metabotropic Glutamate Biochemistry Chemical synthesis chemistry.chemical_compound Lactones Structure-Activity Relationship Cricetulus Cricetinae Drug Discovery Osteoarthritis Structure–activity relationship Animals Sulfones Receptor Molecular Biology Bicyclic molecule Cyclooxygenase 2 Inhibitors Aryl Organic Chemistry Rats Metabotropic receptor Pyrimidines chemistry Excitatory Amino Acid Antagonists Molecular Medicine Calcium Indicators and Reagents Joints
Zdroj:	Bioorganicmedicinal chemistry letters. 17(19)
ISSN:	0960-894X
Popis:	A novel series of potent 2-aryl pyrido[2,3-d]pyrimidine mGlu5 receptor antagonists are described. The synthesis and pharmacological activities of these analogs are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfcd9f8f8c58ec833be687d17fff294 https://pubmed.ncbi.nlm.nih.gov/17723296 Zobrazit plný text záznamu Full Text from ScienceDirect