Diagnosis of prostate cancer in one day: The benefits of cytology in tumour detection
| Autor: | V. Ondet, Raphaële Renard-Penna, Geraldine Cancel-Tassin, Eva Compérat, Olivier Cussenot |
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| Přispěvatelé: | Groupe Hospitalier Diaconesses Croix Saint-Simon, Service de Pathologie [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Groupe de Recherche Clinique Onco-Urologie Prédictive [CHU Tenon] (GRC 5), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Radiologie Polyvalente Diagnostique et Interventionnelle [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service d'urologie [CHU Tenon] |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Histology Concordance Cytodiagnosis 030209 endocrinology & metabolism urologic and male genital diseases Stain Pathology and Forensic Medicine 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate TUMOUR DETECTION Cytology medicine Biomarkers Tumor Humans Imprint cytology p63 immunocytology business.industry racemase Tumor Suppressor Proteins Biopsy Needle Prostatic Neoplasms General Medicine Middle Aged medicine.disease 3. Good health DNA-Binding Proteins medicine.anatomical_structure 030220 oncology & carcinogenesis cytology Radiology business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Transcription Factors |
| Zdroj: | Cytopathology Cytopathology, Wiley-Blackwell, 2020, 32 (2), pp.211-216. ⟨10.1111/cyt.12930⟩ |
| ISSN: | 1365-2303 0956-5507 |
| DOI: | 10.1111/cyt.12930⟩ |
| Popis: | International audience; ObjectiveProstate cancer (PCa) is a frequent and mortal disease. The aim of this study was to introduce a “diagnosis and handling of PCa in one day” concept, accelerating the handling of PCa patients by giving diagnostic results within 3 hours with the help of prostate cytology. Standard histology served as the control.Material and methodsAfter multiparametric MRI, prostate biopsies were taken and one was used for imprint cytology on superfrost slides. The cytology samples were stained by p63/p504s double staining, a standard stain in PCa histology, followed by on‐site interpretation.ResultsAmong 129 patients, 39.5% had a prior history of PCa and were either under active surveillance or had been treated by focal therapy. The others came with suspicion of PCa. In 80.8% of the cases, the cytology and histology results agreed. In low‐grade PCa the detection with cytology was more difficult with 72.4% agreement, whereas for intermediate and high‐grade PCa the concordance with histology was 81.8 and 90%, respectively. False positive cases were less than 4.0%.ConclusionCytology of the prostate is unusual, but our study is the first to show it is feasible and gives immediate results that are satisfactory, especially in more aggressive cases. Immunocytology can be easily integrated into the laboratory. Our technique allows quicker handling of PCa, which can soften the psychological impact on men waiting for the diagnosis of PCa. |
| Databáze: | OpenAIRE |
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