Acute intraperitoneal administration of taurine decreases the glycemia and reduces food intake in type 1 diabetic rats
| Autor: | Ricardo Schneider, Luana Freese, Greice Caletti, Ana Lúcia Hoefel, Rosane Gomez, Alana Witt Hansen, Solange Bandiera, Helena Maria Tanhauser Barros, Bruno Dutra Arbo, Luiz Carlos Rios Kucharski, Rianne Remus Pulcinelli |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Taurine Antioxidant medicine.medical_treatment Glucagon Streptozocin Diabetes Mellitus Experimental Eating 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Hypoglycemic Agents 030212 general & internal medicine Rats Wistar Pharmacology biology Glycogen business.industry Leptin Insulin General Medicine Streptozotocin Insulin receptor Diabetes Mellitus Type 1 030104 developmental biology Endocrinology chemistry biology.protein business Injections Intraperitoneal medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy. 103:1028-1034 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2018.04.131 |
| Popis: | Taurine, an amino acid with antioxidant and osmoregulatory properties, has been studied for its possible antidiabetic properties in type 1 and type 2 diabetic animals. In type 2 diabetic mice, taurine decreases blood glucose through increased insulin secretion and insulin receptor sensitization. However, insulin is absent in type 1 diabetic individuals. The aim of this study was to evaluate the effects of taurine on parameters related to the energy balance that could explain the metabolic action of this amino acid in type 1 diabetic rats. Control and streptozotocin-induced diabetic rats received saline or taurine (100 mg/kg/day), intraperitoneally, for 30 days. Parameters such as palatable food intake, gastrointestinal transit rate, serum glucose, insulin, leptin, and glucagon levels were measured 60 min after the last taurine administration. Liver, kidneys, heart, and retroperitoneal fat were dissected and weighted. Glycogen levels were measured in the liver and soleus muscle. Our results showed that acute taurine administration decreased glycemia. It also decreased food intake in diabetic rats, without affecting other metabolic parameters. Altogether, our results suggest that in type 1 diabetic rats, taurine decreases blood glucose by a non-insulin-dependent mechanism. Due to the safety profile of taurine, and its effect on glycemia, this amino acid may help to design new drugs to add benefit to insulin therapy in type 1 diabetic individuals. |
| Databáze: | OpenAIRE |
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