The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes
| Autor: | Simon Shaw, Kai Blin, Marnix H. Medema, Tilmann Weber, Satria A. Kautsar |
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| Rok vydání: | 2020 |
| Předmět: |
Database
Microbial Genomes AcademicSubjects/SCI00010 Bioinformatics business.industry Modular design Biology computer.software_genre Genome Biosynthetic Pathways Enzymes Search Engine Databases as Topic Multigene Family Bioinformatica Genetics Life Science Database Issue Data Mining Genome mining EPS business computer |
| Zdroj: | Blin, K, Shaw, S, Kautsar, S A, Medema, M H & Weber, T 2021, ' The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes ', Nucleic Acids Research, vol. 49, no. D1, pp. D639–D643 . https://doi.org/10.1093/nar/gkaa978 Nucleic Acids Research Nucleic acids research, 49(D1), D639-D643 Nucleic acids research 49 (2021) D1 |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | Microorganisms produce natural products that are frequently used in the development of antibacterial, antiviral, and anticancer drugs, pesticides, herbicides, or fungicides. In recent years, genome mining has evolved into a prominent method to access this potential. antiSMASH is one of the most popular tools for this task. Here, we present version 3 of the antiSMASH database, providing a means to access and query precomputed antiSMASH-5.2-detected biosynthetic gene clusters from representative, publicly available, high-quality microbial genomes via an interactive graphical user interface. In version 3, the database contains 147 517 high quality BGC regions from 388 archaeal, 25 236 bacterial and 177 fungal genomes and is available at https://antismash-db.secondarymetabolites.org/. Graphical Abstract Graphical AbstractThe antiSMASH database was updated to version 3, now containing 147 517 secondary/specialized metabolite biosynthetic gene clusters (BGCs) originating from 25 236 bacterial, 388 archaeal and 177 fungal genomes. The database provides interactive access to the detailed annotation of each BGC that was generated with the most recent version of antiSMASH (v5.2). |
| Databáze: | OpenAIRE |
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