Extramedullary Solitary Plasmacytoma of the Head and Neck
| Autor: | Jacques Bosq, Guy Schwaab, Jean-Nicolas Munck, Michel-Andre Hotz |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty medicine.medical_treatment Immunoglobulins Plasma cell Malignancy Immunophenotyping 03 medical and health sciences 0302 clinical medicine Antigens CD immune system diseases hemic and lymphatic diseases medicine Humans 030223 otorhinolaryngology Multiple myeloma Aged Aged 80 and over business.industry General Medicine Middle Aged medicine.disease Lymphoma Radiation therapy medicine.anatomical_structure Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Monoclonal Plasmacytoma Female business |
| Zdroj: | Annals of Otology, Rhinology & Laryngology. 108:495-500 |
| ISSN: | 1943-572X 0003-4894 |
| DOI: | 10.1177/000348949910800514 |
| Popis: | Monoclonal extramedullary plasmacytoma (EMP) is a rare, low-grade lymphoma found predominantly in the head and neck region. Only since the introduction of immunophenotyping techniques 2 decades ago has it been possible to differentiate EMP from benign polyclonal plasma cell proliferation. The purpose of this study was to trace the evolutionary profile of the disease under consideration of monoclonality assessment. The records of 24 patients with morphologically diagnosed EMP treated in a single institution underwent clinical and pathological review. Only 14 patients had true monoclonal plasmacytoma. No EMP-related deaths occurred. Two patients had local recurrence, and 2 patients developed multiple myeloma. Review of the literature confirms the low-grade malignancy of EMP. Diagnostic procedures must exclude benign polyclonal plasmacytoma, multiple myeloma, and solitary bone plasmacytoma. The slow natural progression of the disease and the rarity of secondary multiple myeloma favor nonmutilating local surgery whenever possible to avoid the long-term sequelae of radiotherapy. |
| Databáze: | OpenAIRE |
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