Biopharmaceutical liquid formulation: a review of the science of protein stability and solubility in aqueous environments
| Autor: | Robert J. Falconer, Lauren Platts, Jordan W. Bye |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Aqueous solution
Protein Stability Chemistry Drug Storage Water Bioengineering General Medicine Research findings Applied Microbiology and Biotechnology Recombinant Proteins Biopharmaceutics Organic molecules Protein stability Biopharmaceutical industry Biopharmaceutical Drug Stability Solubility Chemical engineering Biochemical engineering Protein stabilization Biotechnology |
| Zdroj: | Biotechnology Letters. 36:869-875 |
| ISSN: | 1573-6776 0141-5492 |
| Popis: | Formulation scientists employed in the biopharmaceutical industry face the challenge of creating liquid aqueous formulations for proteins that never had evolutionary pressure to be exceptionally stable or soluble. Yet commercial products usually need a shelf life of 2 years to be economically viable. The research done in this field is dominated by physical chemists who have developed theories like preferential interaction, preferential hydration and excluded volume to explain the mechanisms for the interaction between salt, small organic molecules and proteins. This review aims to translate the research findings on protein stability and solubility produced by the physical chemists and make it accessible to formulation scientists working within the biopharmaceutical industry. |
| Databáze: | OpenAIRE |
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