Investigation of pharmaceutical high-performance liquid chromatography assay bias using experimental design
| Autor: | Mark Alasandro, Xiaohong Chen, Kelly Glancy, Jian-Ge Chen |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Chromatography
Chemistry Organic Chemistry Reproducibility of Results General Medicine Biochemistry High-performance liquid chromatography Analytical Chemistry Chemometrics Hplc assay Pharmaceutical Preparations Spectrophotometry Ultraviolet Quantitative analysis (chemistry) Chromatography High Pressure Liquid |
| Zdroj: | Journal of Chromatography A. 917:63-73 |
| ISSN: | 0021-9673 |
| DOI: | 10.1016/s0021-9673(01)00670-7 |
| Popis: | This article presents a systematic approach to investigate, document, and eliminate pharmaceutical HPLC assay bias using experimental design. This is the first article to describe the application of experimental design in the area of assay bias. It is found that both formulation and analytical variables can contribute to pharmaceutical HPLC assay bias using model compounds and formulations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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