Intrapartum Transmission After Mucosal Exposure to HIV Was Not Observed With Single-Dose Nevirapine for Mother and Child
| Autor: | Angelika Mayer, Shirin Simo, Kizito Mugenyi, Gundel Harms, Moses Ali, Heiko Karcher, Andrea Kunz, Michael Kurowski |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Nevirapine Anti-HIV Agents Population Oropharynx HIV Infections Cervix Uteri Pregnancy medicine Humans Childbirth Uganda Pharmacology (medical) Pregnancy Complications Infectious education Prospective cohort study education.field_of_study Mucous Membrane biology Transmission (medicine) Obstetrics business.industry Infant Newborn Infant virus diseases biology.organism_classification medicine.disease Infectious Disease Transmission Vertical Infectious Diseases Clinical research Vagina Lentivirus Immunology HIV-1 Female business medicine.drug |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 44:562-565 |
| ISSN: | 1525-4135 |
| DOI: | 10.1097/qai.0b013e31802f853f |
| Popis: | Background: Intrapartum transmission of HIV has been reported to be associated with HIV in oropharyngeal secretions (OPSs) of the child. In this study, we analyze the frequency of intrapartum transmission after mucosal exposure to HIV after administration of single-dose nevirapine. Methods: Eighty mothers and their children participating in a prevention of mother-to-child transmission of HIV program in Uganda who took a single dose of nevirapine according to the HIVNET012 protocol participated in the study. HIV-1 was quantified by polymerase chain reaction (PCR) in the mothers' and children's plasma, in cervicovaginal secretions (CVSs), and in the children's OPSs. Intrapartum transmission was defined as a positive HIV-1 RNA PCR result at week 1 or 2 after birth and a previously negative PCR result. Results: Ninety-seven percent of children had detectable nevirapine in their OPS (median = 592 ng/mL). Fifty-seven (81%) children had HIV-negative OPSs, and 13 (19%) had HIV-positive OPSs. All children of mothers with HIV-negative CVSs had HIV-negative OPSs. HIV-1 levels of OPSs and CVSs correlated (r = 0.33, P = 0.027). None of the babies with detectable HIV-1 in the OPSs became infected by means of intrapartum transmission. Conclusion: Intrapartum HIV infection was not observed after mucosal exposure to HIV-1 after administration of a single dose of nevirapine to the mother and child. |
| Databáze: | OpenAIRE |
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