Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19

Autor:	George R. Abraham, Rhoda E. Kuc, Magnus Althage, Peter J. Greasley, Philip Ambery, Janet J. Maguire, Ian B. Wilkinson, Stephen P. Hoole, Joseph Cheriyan, Anthony P. Davenport
Rok vydání:	2022
Předmět:	Endothelin Receptor Antagonists Endothelin-1 Receptors Endothelin COVID-19 Endothelial Cells Humans Vasoconstrictor Agents Cardiology and Cardiovascular Medicine Receptor Endothelin A Molecular Biology
Zdroj:	Journal of molecular and cellular cardiology. 167
ISSN:	1095-8584
Popis:	Virus induced endothelial dysregulation is a well-recognised feature of severe Covid-19 infection. Endothelin-1 (ET-1) is the most highly expressed peptide in endothelial cells and a potent vasoconstrictor, thus representing a potential therapeutic target. ET-1 plasma levels were measured in a cohort of 194 Covid-19 patients stratified according to the clinical severity of their illness. Hospitalised patients, including those who died and those developing acute myocardial or kidney injury, had significantly elevated ET-1 plasma levels during the acute phase of infection. The results support the hypothesis that endothelin receptor antagonists may provide clinical benefit for certain Covid-19 patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda8d2a56898a3e54fc02bf5c4c7a3aa https://pubmed.ncbi.nlm.nih.gov/35339512 Zobrazit plný text záznamu Full Text from ScienceDirect