Osteochondroma in Laboratory Rats: A Report of 3 Cases in a Fischer-344, a Sprague-Dawley, and a Wistar Rat
| Autor: | Ulrich Mohr, Thomas Nolte, Eberhard Karbe, Heinrich Ernst, Erich Sander |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
0301 basic medicine Osteochondroma Solitary Osteochondroma Pathology medicine.medical_specialty Multiple osteochondroma 040301 veterinary sciences Bone Neoplasms Hindlimb Lumbar vertebrae Toxicology Pathology and Forensic Medicine Rats Sprague-Dawley 0403 veterinary science 03 medical and health sciences Lumbar medicine Animals Rats Wistar Molecular Biology Endochondral ossification business.industry Hyaline cartilage 04 agricultural and veterinary sciences Cell Biology Anatomy medicine.disease Rats Inbred F344 Rats 030104 developmental biology medicine.anatomical_structure Female business |
| Zdroj: | Toxicologic Pathology. 20:264-267 |
| ISSN: | 1533-1601 0192-6233 |
| DOI: | 10.1177/019262339202000214 |
| Popis: | Three cases of osteochondroma in a male Sprague-Dawley (SD) rat, a female Fischer (F344) rat, and a male Wistar rat are described. The rats were aged between 26 and 30 months. All osteochondromas were considered to be of spontaneous origin. The Wistar rat had multiple osteochondromas on both hind legs, the skull base, and a lumbar vertebra, whereas each of the F344 and SD rats was affected by a solitary osteochondroma, also on a lumbar vertebra. The lumbar osteochondromas were similar in appearance in all rats and consisted of a central core of trabecular bone, interspersed with fatty marrow and covered by a cap of hyaline cartilage. The additional tumors in the Wistar rat represented different developmental stages of osteochondroma with or without endochondral activity. The osteochondromas in the rats were morphologically similar to those described in humans and some domestic animal species. |
| Databáze: | OpenAIRE |
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