Fredericamycin A a new antitumor antibiotic. I. Production, isolation and physicochemical properties
| Autor: | Toussaint Mw, Kevin M. Byrne, Ronald M. Stroshane, Geoghegan Rf, Richard White, Aline L. Garretson, Ramesh C. Pandey, Adorjan Aszalos, C. C. Kalita, Tena T. Wei |
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| Rok vydání: | 1981 |
| Předmět: |
Pharmacology
Antibiotics Antineoplastic Chemical Phenomena Chemistry Physical Stereochemistry medicine.drug_class Antibiotics Thin layer Streptomyces griseus Fredericamycin A Biology Isoquinolines biology.organism_classification Biological property Fermentation Drug Discovery medicine Mass spectrum Spiro Compounds Chromatography Thin Layer Chromatography High Pressure Liquid |
| Zdroj: | The Journal of Antibiotics. 34:1389-1401 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.34.1389 |
| Popis: | A new antitumor antibiotic, fredericamycin A (FCRC-A48, NSC-305263), has been isolated from a strain of Streptomyces griseus (FCRC-48). Based on its unique ultraviolet-visible spectrum, infrared spectrum, proton and carbon-13 nuclear magnetic resonance spectra and mass spectra, it is judged to be a novel acid-base indicator type of compound. Its production, isolation and physicochemical properties are discussed. The isolation, ultraviolet-visible spectrum and some biological properties of two minor components, fredericamycin B and fredericamycin C, are also described. |
| Databáze: | OpenAIRE |
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