Transmission dynamics of HIV-1 subtype B in the Basque Country, Spain
| Autor: | Michael M. Thomson, Elena Delgado, Juan Ángel Patiño-Galindo, Aurora Fernández-García, María Teresa Cuevas, Rafael Nájera, Ramón Cisterna, Fernando González-Candelas, Leyre Mónica López-Soria, María Jesús Lezaun, Lucía Pérez-Álvarez, Gustavo Cilla, José Antonio Iribarren |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) Time Factors Genotype Population Human immunodeficiency virus (HIV) HIV Infections Biology medicine.disease_cause Microbiology Virus Drug Users 03 medical and health sciences HIV Protease Drug Resistance Viral Genetics medicine Antiretroviral treatment Humans Protease inhibitor (pharmacology) Homosexuality Male education Molecular Biology Phylogeny Ecology Evolution Behavior and Systematics education.field_of_study Intravenous drug Sequence Analysis RNA Transmission (medicine) virus diseases 030112 virology Virology HIV Reverse Transcriptase Reverse transcriptase 030104 developmental biology Infectious Diseases Spain Mutation Infecció HIV-1 |
| Zdroj: | Patiño-Galindo, Juan Ángel Thomson, Miguel M. Pérez-Álvarez, Lucía Delgado, Elena Cuevas, María Teresa Fernández-García, Aurora Nájera Morrondo, Rafael Iribarren, José A. Cilla, Gustavo López-Soria, Leyre Lezaun, María J. Cisterna, Ramón González Candelas, Fernando 2016 Transmission dynamics of HIV-1 subtype B in the Basque Country, Spain Infection Genetics And Evolution 40 91 97 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname |
| ISSN: | 1567-1348 |
| Popis: | This work was aimed to study the HIV-1 subtype B epidemics in the Basque Country, Spain. 1727 HIV-1 subtype B sequences comprising protease and reverse transcriptase (PR/RT) coding regions, sampled between 2001 and 2008, were analyzed. 156 transmission clusters were detected by means of phylogenetic analyses. Most of them comprised less than 4 individuals and, in total, they included 441 patients. Six clusters comprised 10 or more patients and were further analyzed in order to study their origin and diversification. Four clusters included men who had unprotected homosexual sex (MSM), one group was formed by intravenous drug users (IDUs), and another included both IDUs and people infected through unprotected heterosexual sex (HTs). Most of these clusters originated from the mid-1980s to the mid-1990s. Only one cluster, formed by MSM, originated after 2000. The time between infections was significantly lower in MSM groups than in those containing IDUs (P-value < 0.0001). Nucleoside RT and non-nucleoside RT inhibitor (NRTI and NNRTI)-resistance mutations to antiretroviral treatment were found in these six clusters except the most recent MSM group, but only the IDU clusters presented protease inhibitor (PI)-resistance mutations. The most prevalent mutations for each inhibitor class were PI L90M, NRTI T215D/Y/F, and NNRTI K103N, which were also among the most prevalent resistant variants in the whole dataset. In conclusion, while most infections occur as isolated introductions into the population, the number of infections found to be epidemiologically related within the Basque Country is significant. Public health control measures should be reinforced to prevent the further expansion of transmission clusters and resistant mutations occurring within them. |
| Databáze: | OpenAIRE |
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