Vaccination of gnotobiotic piglets against Helicobacter pylori
| Autor: | S. Krakowka, K. A. Eaton, Susan S. Ringler |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Swine
animal diseases medicine.medical_treatment Spirillaceae Administration Oral Inflammation Microbiology Helicobacter Infections fluids and secretions Oral administration medicine Immunology and Allergy Animals Germ-Free Life integumentary system biology Helicobacter pylori Vaccination bacterial infections and mycoses biology.organism_classification Antibodies Bacterial Infectious Diseases Gastritis Immunology Bacterial Vaccines biology.protein medicine.symptom Antibody Adjuvant |
| Zdroj: | The Journal of infectious diseases. 178(5) |
| ISSN: | 0022-1899 |
| Popis: | To determine the effect of oral adjuvant-assisted and parenteral vaccination, germ-free piglets were vaccinated orally with and without labile toxin adjuvant or parenterally and challenged with viable Helicobacter pylori. All prechallenge vaccination regimens induced anti-H. pylori antibodies and suppressed bacterial colonization, but no vaccination regime completely prevented infection. Parenteral vaccination given after infection had no effect on bacterial colonization. Lymphocytic gastritis was present in all piglets challenged with live bacteria regardless of vaccination status. Neutrophilic gastritis was present in vaccinated challenged piglets but not in infected, unvaccinated piglets. Gastritis was not present in uninfected control piglets regardless of vaccination status. In gnotobiotic piglets, vaccination suppresses but does not prevent infection by H. pylori, and parenteral vaccination does not cure infected piglets. Vaccination does not ameliorate gastritis due to H. pylori in piglets but does induce neutrophilic gastric inflammation in some infected piglets. |
| Databáze: | OpenAIRE |
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