Distinctive Pathophysiology Underlying Constipation in Parkinson’s Disease: Implications for Cognitive Inefficiency
| Autor: | Aisha D. Augustin, Bu Hayee, Andre Charlett, Clive Weller, Rosalind M Tucker, David Taylor, Ingvar Bjarnason, Sylvia M. Dobbs, Chianna Umamahesan, R. John Dobbs, Suzanne Ryan |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Constipation Parkinson's disease Bradyphrenia lcsh:Medicine Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Effects of sleep deprivation on cognitive performance Depression (differential diagnoses) business.industry lcsh:R General Medicine functional constipation medicine.disease anxiety nervous system diseases Mood depression Parkinson’s disease colonic transit-time Anxiety Functional constipation 030211 gastroenterology & hepatology medicine.symptom business cognitive-processing time 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 9, Iss 1916, p 1916 (2020) Volume 9 Issue 6 |
| ISSN: | 2077-0383 |
| Popis: | Depression is associated with constipation within and outside Parkinson&rsquo s disease (PD). Since inefficient cognitive-processing (bradyphrenia) features in PD and an enterokinetic agent improved cognitive performance in healthy individuals, bradyphrenia may be associated with constipation. We aim to define the archetypical bowel function of PD, and its association with cognition, mood, and motor features within and outside PD. We assessed colonic transit time (oral radio-opaque markers over 6 days), bowel function and psychometric questionnaires and measures of PD facets, including bradyphrenia, in 58 participants with diagnosed PD, and 71 without (controls). The best abdominal X-ray (day 7) predictors of PD status were total retained marker count and transverse colon segmental delay. However, Rome functional constipation status complemented segmental delay better, giving good specificity (85%) but low sensitivity (56%). Transverse colon marker count appeared to be age-associated only in PD. In PD, those correctly classified by bowel dysfunction had higher depression scores (p = 0.02) and longer cognitive-processing times than the misclassified (p = 0.05). Controls misclassified as PD by bowel dysfunction had higher depression and anxiety scores than the correctly classified (p = 0.002 and 0.003, respectively), but not slower cognitive processing. Measures of motor features were independent of sub-classification by bowel function in PD and in controls. In conclusion, constipation in PD has distinct localized pathophysiology, and is associated with bradyphrenia. |
| Databáze: | OpenAIRE |
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