Fine Manual Dexterity Assessment After Autologous Neural Cell Ecosystem (ANCE) Transplantation in a Non-human Primate Model of Parkinson’s Disease
| Autor: | Pauline Chatagny, Jean-François Brunet, Eric M. Rouiller, Jérôme Cottet, Michela Fregosi, Laura Carrara, Véronique Moret, Jocelyne Bloch, Simon Borgognon, Simon Badoud |
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| Rok vydání: | 2019 |
| Předmět: |
Parkinson's disease
Cell Transplantation Pilot Projects Transplantation Autologous Motor symptoms 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rating scale Animals Medicine Neural cell 030304 developmental biology 0303 health sciences Non human primate Behavior Animal business.industry MPTP MPTP Poisoning Recovery of Function General Medicine medicine.disease Neostriatum Transplantation Disease Models Animal Macaca fascicularis chemistry Motor Skills Female Motor recovery business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurorehabilitation and Neural Repair. 33:553-567 |
| ISSN: | 1552-6844 1545-9683 |
| DOI: | 10.1177/1545968319850133 |
| Popis: | Background. Autologous neural cell ecosystem (ANCE) transplantation improves motor recovery in MPTP monkeys. These motor symptoms were assessed using semi-quantitative clinical rating scales, widely used in many studies. However, limitations in terms of sensitivity, combined with relatively subjective assessment of their different items, make inter-study comparisons difficult to achieve. Objective. The aim of this study was to quantify the impact of MPTP intoxication in macaque monkeys on manual dexterity and assess whether ANCE can contribute to functional recovery. Methods. Four animals were trained to perform 2 manual dexterity tasks. After reaching a motor performance plateau, the animals were subjected to an MPTP lesion. After the occurrence of a spontaneous functional recovery plateau, all 4 animals were subjected to ANCE transplantation. Results. Two of 4 animals underwent a full spontaneous recovery before the ANCE transplantation, whereas the 2 other animals (symptomatic) presented moderate to severe Parkinson’s disease (PD)-like symptoms affecting manual dexterity. The time to grasp small objects using the precision grip increased in these 2 animals. After ANCE transplantation, the 2 symptomatic animals underwent a significant functional recovery, reflected by a decrease in time to execute the different tasks, as compared with the post-lesion phase. Conclusions. Manual dexterity is affected in symptomatic MPTP monkeys. The 2 manual dexterity tasks reported here as pilot are pertinent to quantify PD symptoms and reliably assess a treatment in MPTP monkeys, such as the present ANCE transplantation, to be confirmed in a larger cohort of animals before future clinical applications. |
| Databáze: | OpenAIRE |
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