Magnetic-Responsive Photosensitizer Nanoplatform for Optimized Inactivation of Dental Caries-Related Biofilms: Technology Development and Proof of Principle

Autor: Abdulrahman A. Balhaddad, Yang Xia, Yucheng Lan, Lamia Mokeem, Maria S. Ibrahim, Michael D. Weir, Hockin H. K. Xu, Mary Anne S. Melo
Rok vydání: 2021
Předmět:
Zdroj: ACS nano. 15(12)
ISSN: 1936-086X
Popis: Conventional antibiotic therapies for biofilm-trigged oral diseases are becoming less efficient due to the emergence of antibiotic-resistant bacterial strains. Antimicrobial photodynamic therapy (aPDT) is hampered by restricted access to bacterial communities embedded within the dense extracellular matrix of mature biofilms. Herein, a versatile photosensitizer nanoplatform (named MagTBO) was designed to overcome this obstacle by integrating toluidine-blue ortho (TBO) photosensitizer and superparamagnetic iron oxide nanoparticles (SPIONs)
Databáze: OpenAIRE