Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses
| Autor: | Hakon Hakonarson, Erin Zullo, Rebecca A. Simmons, Mark W. Russell, Julie S. Moldenhauer, Susan C. Nicolson, J. William Gaynor, Mark P. Johnson, Samuel Parry, Sunkyung Yu, Matthew G. Sampson, Rebecca L. Linn, Jack Rychik, Nancy Burnham, Michal A. Elovitz |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Angiogenesis
Fetal growth Biology lcsh:Computer applications to medicine. Medical informatics Congenital cardiac defects Placental function 03 medical and health sciences 0302 clinical medicine Placenta Biochemistry Genetics and Molecular Biology Genetic variation medicine In patient lcsh:Science (General) Gene 030304 developmental biology Genetics 0303 health sciences Fetus Multidisciplinary medicine.anatomical_structure embryonic structures lcsh:R858-859.7 030217 neurology & neurosurgery Function (biology) lcsh:Q1-390 |
| Zdroj: | Data in Brief Data in Brief, Vol 25, Iss, Pp-(2019) |
| ISSN: | 2352-3409 |
| Popis: | The placenta is a highly vascular structure composed of both maternal and fetal elements. We have determined that damaging variants in genes responsible for the positive regulation of angiogenesis (PRA) (GO:0045766) that are inherited by the fetus impair fetal growth and placental function in pregnancies involving critical congenital cardiac defects (Russell et al., 2019). In this dataset, we present the specific genetic variants identified, describe the parental origin of each variant where possible and present the analyses regarding the potential effects of parental origin of the variant on placental function and fetal growth. The data presented are related to the research article “Damaging variants in pro-angiogenic genes impair growth in fetuses with cardiac defects” (Russell et al., 2019). Keywords: Genetic variation, Placental function, Fetal growth, Congenital cardiac defects |
| Databáze: | OpenAIRE |
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