Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus
| Autor: | Taisa Regina Stumpf, Rosendo A. Yunes, Ricardo José Nunes, Elza de Fátima Albino Smânia, Artur Smânia, Franco Delle Monache, Douglas Bardini Silveira, Lucas Ariel Totaro Garcia, Célia Regina Monte Barardi, Carlos R. Zanetti, Aline Viancelli, Louise Domeneghini Chiaradia, Alessandra Mascarello, Thaís Moreira Osório |
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| Rok vydání: | 2012 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus Clinical Biochemistry Pharmaceutical Science Context (language use) Microbial Sensitivity Tests medicine.disease_cause Staphylococcal infections Biochemistry Microbiology Methicillin Minimum inhibitory concentration chemistry.chemical_compound Chalcones Antibiotic resistance Chlorocebus aethiops Drug Discovery medicine Animals Humans Vero Cells Molecular Biology Oxadiazoles Chemistry Organic Chemistry Hydrazones Dihydrochalcone Staphylococcal Infections medicine.disease Methicillin-resistant Staphylococcus aureus Anti-Bacterial Agents Models Chemical Molecular Medicine Antibacterial activity |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 22:225-230 |
| ISSN: | 0960-894X |
| Popis: | The increase in antibiotic resistance due to multiple factors has encouraged the search for new compounds which are active against multidrug-resistant pathogens. In this context, chalcones, dihydrochalcones, hydrazones and oxadiazoles were tested against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus (MRSA) isolates, which were obtained from clinical laboratories and were characterized as MRSA using traditional and molecular methods. Among 65 tested compounds, two chalcones, one dihydrochalcone and two hydrazones were active against MRSA. Based on the minimal inhibitory concentration and cytotoxicity, hydrazones provided a better selectivity index than chalcones. Active hydrazones are promising antibiotic-like substances and they should be the subject of further microbiological studies. |
| Databáze: | OpenAIRE |
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