Effect of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Capsules on Colistin-Induced Nephrotoxicity
| Autor: | Gamze Talih, Tutkun Talih, Çiğdem Ünal Kantekin, Aliye Esmaoğlu, Yeşim Göçmen, Sevinç Çelik |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Reishi
Nitrogen Capsules Pharmacology Kidney medicine.disease_cause Applied Microbiology and Biotechnology Antioxidants Nephrotoxicity Superoxide dismutase Mice chemistry.chemical_compound Malondialdehyde Drug Discovery polycyclic compounds medicine Animals Blood urea nitrogen chemistry.chemical_classification biology Colistin Superoxide Dismutase Chemistry Glutathione peroxidase Glutathione biochemical phenomena metabolism and nutrition Catalase bacterial infections and mycoses Mice Inbred C57BL Oxidative Stress Creatinine Dietary Supplements biology.protein bacteria lipids (amino acids peptides and proteins) Agaricales Oxidative stress medicine.drug |
| Zdroj: | International Journal of Medicinal Mushrooms. 22:445-453 |
| ISSN: | 1521-9437 |
| DOI: | 10.1615/intjmedmushrooms.2020034229 |
| Popis: | The aim of this experimental study was to investigate the protective effect of Ganoderma lucidum capsules against colistin nephrotoxicity. The study animals were separated into four groups: control, colistin (9 mg/kg), colistin-G. lucidum 50 mg/kg, and colistin-G. lucidum 100 mg/kg. In the colistin group, serum blood urea nitrogen and creatinine values were found to be higher than those of the other groups (p < 0.001). The malondialdehyde, catalase, total oxidative stress, oxidative stress index, and oxidized glutathione values in serum and kidney tissue samples were determined to be higher in the colistin group than in the other groups (p < 0.001). The total antioxidative stress, superoxide dismutase, glutathione peroxidase, and glutathione values measured in the serum and kidney tissue samples were determined to be lower in the colistin group (p < 0.001). Oxidative stress is responsible for tubule damage in colistin nephrotoxicity, and when G. lucidum is used together with colistin, renal damage is reduced. |
| Databáze: | OpenAIRE |
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