Comprehensive Analysis of Long-Range Connectivity from and to the Posterior Parietal Cortex of the Mouse
| Autor: | Sook Jin Son, Joon Ho Choi, John A. Morris, Changkyu Lee, Jong-Cheol Rah, Seung Wook Oh |
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| Rok vydání: | 2020 |
| Předmět: |
Brain Mapping
genetic structures Computer science Cognitive Neuroscience Efferent Posterior parietal cortex Cognition Sensory system Mice Cellular and Molecular Neuroscience medicine.anatomical_structure Categorization Visuospatial perception Parietal Lobe Cortex (anatomy) medicine Animals Attention Nerve Net Association (psychology) Neuroscience psychological phenomena and processes |
| Zdroj: | Cerebral Cortex. 31:356-378 |
| ISSN: | 1460-2199 1047-3211 |
| Popis: | The posterior parietal cortex (PPC) is a major multimodal association cortex implicated in a variety of higher order cognitive functions, such as visuospatial perception, spatial attention, categorization, and decision-making. The PPC is known to receive inputs from a collection of sensory cortices as well as various subcortical areas and integrate those inputs to facilitate the execution of functions that require diverse information. Although many recent works have been performed with the mouse as a model system, a comprehensive understanding of long-range connectivity of the mouse PPC is scarce, preventing integrative interpretation of the rapidly accumulating functional data. In this study, we conducted a detailed neuroanatomic and bioinformatic analysis of the Allen Mouse Brain Connectivity Atlas data to summarize afferent and efferent connections to/from the PPC. Then, we analyzed variability between subregions of the PPC, functional/anatomical modalities, and species, and summarized the organizational principle of the mouse PPC. Finally, we confirmed key results by using additional neurotracers. A comprehensive survey of the connectivity will provide an important future reference to comprehend the function of the PPC and allow effective paths forward to various studies using mice as a model system. |
| Databáze: | OpenAIRE |
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