Prognostic usefulness of plasma monocyte/macrophage and T-lymphocyte activation markers in patients with acute coronary syndromes
| Autor: | Helena Kervinen, Petri T. Kovanen, Kari Pulkki, Matti Mänttäri, Heikki Mäkynen, Timo Palosuo, Maija Kaartinen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Acute coronary syndrome medicine.medical_specialty T-Lymphocytes Myocardial Infarction Lymphocyte Activation Monocytes Angina Internal medicine Blood plasma medicine Humans Angina Unstable Myocardial infarction Chemokine CCL2 Aged Aged 80 and over business.industry Unstable angina Macrophages Syndrome Odds ratio Middle Aged Prognosis medicine.disease Confidence interval Macrophage-Activating Factors Acute Disease Cardiology Female Ischemic chest pain Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American Journal of Cardiology. 94:993-996 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2004.06.052 |
| Popis: | Macrophages and T lymphocytes accumulate and are activated in atherosclerotic plaques. We tested the hypothesis that plasma levels of the monocyte/macrophage and T-lymphocyte activation markers, monocyte chemoattractant protein-1 (MCP-1) and soluble interleukin-2 receptor (sIL-2r), respectively, can be used in acute coronary syndrome classification and risk prediction. Blood samples were collected at hospital admissions of 183 patients who had ischemic chest pain. Of these, 59 had acute myocardial infarction, 60 had unstable angina, and 64 had angina pectoris. No significant differences in the levels or proportions of subjects with increased levels of MCP-1 or sIL-2r were found across groups. During a mean follow-up of 13 months, 117 patients (64%) had a study end point (i.e., cardiac death, recurrent myocardial infarction, unstable angina, or revascularization). Increased levels (above median) of MCP-1 and sIL-2r were associated with increased risk, with odds ratios of 1.85 (95% confidence interval 0.92 to 3.73, p = 0.08) and 2.34 (95% confidence interval 1.16 to 4.71, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect