Specific clones of Staphylococcus lugdunensis may be associated with colon carcinoma
| Autor: | Mari Fukuzawa, Kaoru Yokose, Masae Suzuki, Takashi Kawai, Norihisa Noguchi, Fuminori Moriyasu, Hidemasa Nakaminami, Takeaki Wajima, Masanori Sasatsu |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
clone (Java method) Genotype Colon Adenoma 030106 microbiology Microbial Sensitivity Tests Staphylococcus lugdunensis lcsh:Infectious and parasitic diseases Microbiology 03 medical and health sciences Colon carcinoma Drug Resistance Bacterial Pulsed-field gel electrophoresis Carcinoma medicine Humans lcsh:RC109-216 Typing biology lcsh:Public aspects of medicine Public Health Environmental and Occupational Health lcsh:RA1-1270 General Medicine Staphylococcal Infections biology.organism_classification medicine.disease Antimicrobial digestive system diseases Electrophoresis Gel Pulsed-Field Infectious Diseases Colonic Neoplasms Multilocus Sequence Typing |
| Zdroj: | Journal of Infection and Public Health, Vol 11, Iss 1, Pp 39-42 (2018) |
| ISSN: | 1876-0341 |
| DOI: | 10.1016/j.jiph.2017.03.012 |
| Popis: | Staphylococcus lugdunensis produces a tannase with activity that may be associated with the onset of colon carcinoma. To clarify this feature of colon carcinoma-associated S. lugdunensis, we obtained isolates from healthy subjects and patients with colon adenomas and carcinomas and analyzed their genetic backgrounds. In total, 40 S. lugdunensis isolates from 288 rectal swabs collected between 2002 and 2008 were used. These isolates were classified into four groups according to the diseases of the subjects: healthy (n = 13), colon carcinoma (n = 13), colon adenoma (n = 9), and unknown (n = 5). The isolates were also classified by pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing. In addition, an antimicrobial susceptibility test and detection of resistance genes were performed for all isolates. According to the PFGE analysis, 40 isolates could be classified into five groups. Among the groups, carcinoma and colon adenoma patients were significantly more frequently (40.9%) classified into group D (p |
| Databáze: | OpenAIRE |
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