Clinicopathological significance of tumor cyclin D1 expression in oral cancer
| Autor: | José Antonio Gil-Montoya, Lucía González-Ruiz, Manuel Bravo, Isabel Ruiz-Ávila, Ángela Ayén, Pablo Ramos-García, Miguel Ángel González-Moles |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Proliferation index Carcinogenesis medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Cyclin D1 Biomarkers Tumor medicine Humans Stage (cooking) General Dentistry Aged Cell Proliferation Neoplasm Staging Retrospective Studies Cyclin Aged 80 and over business.industry Cancer 030206 dentistry Cell Biology General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry Phenotype stomatognathic diseases Ki-67 Antigen 030104 developmental biology Otorhinolaryngology Spain Carcinoma Squamous Cell Cancer research Female Mouth Neoplasms business |
| Zdroj: | Archives of Oral Biology. 99:177-182 |
| ISSN: | 0003-9969 |
| DOI: | 10.1016/j.archoralbio.2019.01.018 |
| Popis: | Objective To evaluate the association of cyclin D1 overexpression with clinicopathological parameters classically considered of prognostic value in OSCC (T, N, M, clinical stage, degree of differentiation, invasive morphology and, cellular proliferation index). Design A retrospective immunohistochemical study was conducted of cyclin D1 and ki-67 expression in 68 OSCCs from 54 patients. Cases were scanned using a digital pathology system. The tumor expression of markers was assessed in four randomly selected fields (40x), and a semi-automatized count was conducted of cyclin D1-positive and -negative cells. Results Cyclin D1 overexpression was found in 28.7% of the cases of OSCC. It was significantly and positively associated with the following clinicopathological parameters: low tumor differentiation degree (p = 0.030), invasive morphology (p = 0.045), and proliferative phenotype according to tumor cell ki-67 expression (p = 0.018). Conclusions Cyclin D1 overexpression is an event of oral carcinogenesis associated with clinicopathological parameters classically associated with a poor prognosis in patients with OSCC. |
| Databáze: | OpenAIRE |
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