A protective mechanism against antibiotic-induced ototoxicity: role of prestin
| Autor: | Xiao Hu Zhang, Li Yu, Hsiao Chang Chan, Lai Ling Tsang, Mei Kuen Yu, Yiu Wa Chung, Ai Mei Wang, Hao Tang, Zhen Zhou, Xiaohua Jiang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Cell Physiology Anatomy and Physiology Hearing loss Science Immunology Apoptosis CHO Cells Cell Line Motor protein Mice Cricetulus Ototoxicity Downregulation and upregulation Kanamycin Cricetinae Hair Cells Auditory medicine otorhinolaryngologic diseases Animals Prestin Ear Diseases Hearing Loss Biology Cochlea Epithelial polarity Mice Inbred BALB C Multidisciplinary biology Molecular Motor Proteins Immunity medicine.disease Innate Immunity Cell biology Anti-Bacterial Agents Cytoprotection biology.protein Medicine sense organs Fluid Physiology medicine.symptom Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 6, Iss 2, p e17322 (2011) |
| ISSN: | 1932-6203 |
| Popis: | Hearing loss or ototoxicity is one of the major side effects associated with the use of the antibiotics, particularly aminoglycosides (AGs), which are the most commonly used antibiotics worldwide. However, the molecular and cellular events involved in the antibiotic-induced ototoxicity remains unclear. In the present study, we test the possibility that prestin, the motor protein specifically expressed in the basolateral membrane of outer hair cells (OHCs) in the cochlea with electromotility responsible for sound amplification, may be involved in the process of AG-induced apoptosis in OHCs. Our results from both mice model and cultured cell line indicate a previously unexpected role of prestin, in mediating antibiotic-induced apoptosis, the effect of which is associated with its anion-transporting capacity. The observed downregulation of prestin mRNA prior to detectable apoptosis in OHCs and hearing loss in the antibiotic-treated mice is interesting, which may serve as a protective mechanism against hearing loss induced by AGs in the early stage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|