PD06 - Early elevated blood eosinophils are predictive for the development of atopic dermatitis in an atopic birth cohort
| Autor: | Georg Menke, Susanne Lau, Stock Philippe, Kurt Zimmermann, Thomas Geske, Kerstin Gerhold, Siri Rossberg |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Pulmonary and Respiratory Medicine
Pediatrics medicine.medical_specialty Treated group Allergy business.industry Immunology Target groups Atopic dermatitis Eosinophil medicine.disease Placebo Elevated blood medicine.anatomical_structure Internal medicine medicine Immunology and Allergy Poster Discussion Presentation Birth cohort business |
| Zdroj: | Clinical and Translational Allergy |
| ISSN: | 2045-7022 |
| DOI: | 10.1186/2045-7022-4-s1-p6 |
| Popis: | At 4 weeks of life and 7 months of life, respectively, 233/ 559 and 107/467 infants showed elevated blood eosinophils counts in the total study group. Elevated blood eosinophils observed at 4 weeks were significantly associated with the occurrence of AD in the whole study group at the time points 7 months (p =0.0073), one year (p=0.0035), two years (p=0.0069) and three years (p=0.006) of life. This observation was seen in the active group as well as the placebo treated group. Blood eosinophil counts at 7 months of life showed only borderline significance for developing AD (p=0.06) at the same age, and blood eosinophil counts at one year of life showed no association with AD. Conclusion Elevated blood eosinophils at age 4 weeks of life seem to be of predictive value for the onset of atopic dermatitis in infancy and early childhood in a high risk birth cohort. Eosinophil counts later in infancy were less correlated with AD prevalence. Early eosinophil counts can therefore be helpful for counseling the parents but furthermore can identify target groups for interventional trials aiming at allergy prevention. |
| Databáze: | OpenAIRE |
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