Fatal hepatic and renal toxicity as a complication of trabectedin therapy for radiation-induced sarcoma
| Autor: | Amy M. Pick, Kelly K. Nystrom |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Neoplasms Radiation-Induced medicine.medical_treatment Dioxoles Skull Base Neoplasms Gastroenterology chemistry.chemical_compound Fatal Outcome Tetrahydroisoquinolines Internal medicine medicine Humans Pharmacology (medical) Antineoplastic Agents Alkylating Blood urea nitrogen Trabectedin Dexamethasone Aged Creatinine business.industry Sarcoma Acute Kidney Injury Liver Failure Acute medicine.disease Surgery Oncology chemistry Toxicity Hemodialysis Chemical and Drug Induced Liver Injury Complication business medicine.drug |
| Zdroj: | Journal of Oncology Pharmacy Practice. 16:269-272 |
| ISSN: | 1477-092X 1078-1552 |
| DOI: | 10.1177/1078155209352821 |
| Popis: | Trabectedin therapy was prescribed for a patient with radiation-induced sarcoma. Two doses of trabectedin were given before therapy was discontinued with the patient experiencing renal and liver failure. Despite discontinuing trabectedin the patient continued to experience increases in liver transaminases, bilirubin, blood urea nitrogen, and serum creatinine. Hemodialysis was initiated with no improvement. With all other causes being ruled out, trabectedin likely caused hepatic and renal failure leading to death in this patient. Recent literature suggests that patients may benefit from prophylactic dexamethasone as a means of reducing hepatic toxicity. |
| Databáze: | OpenAIRE |
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