Expression pattern of zcchc24 during early Xenopus development
| Autor: | José António Belo, Ana Catarina De-Jesus, Ana Rita Serralheiro, José M. Inácio, Marta Vitorino, Elizabeth Correia |
|---|---|
| Přispěvatelé: | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) |
| Rok vydání: | 2014 |
| Předmět: |
Embryology
Mesoderm Embryo Nonmammalian animal structures Molecular Sequence Data Xenopus Xenopus Proteins Biology Heart development FGF and mesoderm formation Xenopus laevis Neural crest 03 medical and health sciences 0302 clinical medicine Zinc finger medicine Animals Zcchc24 Amino Acid Sequence Cloning Molecular In Situ Hybridization 030304 developmental biology Genetics Regulation of gene expression 0303 health sciences Sequence Homology Amino Acid Embryogenesis Gene Expression Regulation Developmental RNA-Binding Proteins Heart Gastrula biology.organism_classification Cell biology Branchial Region medicine.anatomical_structure Somites Neurula embryonic structures NODAL Somitogenic mesoderm 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | The International Journal of Developmental Biology. 58:45-50 |
| ISSN: | 0214-6282 |
| DOI: | 10.1387/ijdb.130261jb |
| Popis: | M Vitorino and J M Inacio are recipients of a F.C.T Post-Doc fellowship with reference SFRH/BPD/65923/2009 and SFRH/BPD/41081/2007, respectively. Elizabeth Correia is recipient of a F.C.T.B.I. fellowship (PTDC/SAU-BID/114902/2009). This work has been supported by research grants from F.C.T and from IBB/CBME, LA to J.A. Belo in the frame of Project refo Pest-OE/EQB/LA0023/2013. We report the expression pattern of a novel Xenopus laevis gene, zcchc24, which encodes a protein containing two zinc finger domains from the zf-CCHC and zf-3CxxC superfamilies. This protein shares >84% amino acid identity with its vertebrate homologues. During X. laevis embryonic development, zcchc24 is expressed at gastrula stages in the dorsal mesoderm, including the cardiac precursors region. During neurula stages, zcchc24 is expressed as two stripes in the dorsal region, more precisely, in the somitogenic mesoderm until the cardiac mesoderm. At early tailbud stages, zcchc24 continues to be expressed in these regions, but starts to be expressed in the migrating neural crest. Later, this gene is expressed in the head, branchial arches, heart and somites. The zinc finger domains present in Zcchc24 protein and its dynamic gene expression pattern suggest that Zcchc24 might be involved in the regulation of heart, somites and of branchial arch formation/patterning, namely in the regulation of apoptosis. publishersversion published |
| Databáze: | OpenAIRE |
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