Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors
| Autor: | Daniel Clayburgh, V. Liana Tsikitis, Jared M. Fischer, Jose L. Montoya Mira, Melissa H. Wong, Matthew S. Dietz, Erik A. Burlingame, Kristen E. Limbach, Alison H. Skalet, Zahi Mitri, Yuki Chin, Jerry J. Jaboin, Su Ellen J. Pommier, Michael S. Parappilly, Gordon B. Mills, John R. Swain, Jeremy Cetnar, Luai Zarour, Brett C. Sheppard, Joe W. Gray, Yu-Jui Chiu, Charles E. Gast, Rodney F. Pommier, Young Hwan Chang, Koei Chin, Jennifer Eng, Ajay Sapre, Charles D. Lopez, Austin Gower, Thomas L. Sutton, Brett S. Walker, Skye C. Mayo, Ariana Sattler, Sidharth K. Sengupta |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Adolescent Science Tumour heterogeneity Cell Population Breast Neoplasms Hybrid Cells Biology Article Tumour biomarkers Mice 03 medical and health sciences 0302 clinical medicine Circulating tumor cell Antigen Neoplasms Biomarkers Tumor medicine Animals Humans Neoplasm Invasiveness Child education Cells Cultured Aged Aged 80 and over education.field_of_study Disseminated Tumor Cell Multidisciplinary Cancer stem cells Cancer Middle Aged Neoplastic Cells Circulating medicine.disease Phenotype 030104 developmental biology medicine.anatomical_structure Child Preschool 030220 oncology & carcinogenesis Cancer research Medicine Female Stem cell Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Metastatic progression defines the final stages of tumor evolution and underlies the majority of cancer-related deaths. The heterogeneity in disseminated tumor cell populations capable of seeding and growing in distant organ sites contributes to the development of treatment resistant disease. We recently reported the identification of a novel tumor-derived cell population, circulating hybrid cells (CHCs), harboring attributes from both macrophages and neoplastic cells, including functional characteristics important to metastatic spread. These disseminated hybrids outnumber conventionally defined circulating tumor cells (CTCs) in cancer patients. It is unknown if CHCs represent a generalized cancer mechanism for cell dissemination, or if this population is relevant to the metastatic cascade. Herein, we detect CHCs in the peripheral blood of patients with cancer in myriad disease sites encompassing epithelial and non-epithelial malignancies. Further, we demonstrate that in vivo-derived hybrid cells harbor tumor-initiating capacity in murine cancer models and that CHCs from human breast cancer patients express stem cell antigens, features consistent with the potential to seed and grow at metastatic sites. Finally, we reveal heterogeneity of CHC phenotypes reflect key tumor features, including oncogenic mutations and functional protein expression. Importantly, this novel population of disseminated neoplastic cells opens a new area in cancer biology and renewed opportunity for battling metastatic disease. |
| Databáze: | OpenAIRE |
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