Sugar End-Capped Poly-d,l-lactides as Excipients in Oral Sustained Release Tablets
| Autor: | Osmo Antikainen, Mohammed Lahcini, Timo Repo, Jouko Yliruusi, Sirpa Vuorinen, Jyrki Heinämäki |
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| Rok vydání: | 2009 |
| Předmět: |
Polymers
Polyesters Administration Oral Pharmaceutical Science Excipient Aquatic Science Excipients chemistry.chemical_compound Spectroscopy Fourier Transform Infrared Drug Discovery Polymer chemistry medicine Technology Pharmaceutical Lactic Acid Ecology Evolution Behavior and Systematics chemistry.chemical_classification Calorimetry Differential Scanning Ecology Chemistry Methylglucosides General Medicine Polymer Biodegradable polymer Microcrystalline cellulose Monomer Solubility Polymerization Delayed-Action Preparations Drug delivery Powders Drug carrier Agronomy and Crop Science Tablets Research Article Nuclear chemistry medicine.drug |
| Zdroj: | AAPS PharmSciTech. 10:566-573 |
| ISSN: | 1530-9932 |
| DOI: | 10.1208/s12249-009-9247-9 |
| Popis: | Sugar end-capped poly-D,L-lactide (SPDLA) polymers were investigated as a potential release controlling excipient in oral sustained release matrix tablets. The SPDLA polymers were obtained by a catalytic ring-opening polymerization technique using methyl alpha-D-gluco-pyranoside as a multifunctional initiator in the polymerization. Polymers of different molecular weights were synthesized by varying molar ratios of monomer/catalyst. The matrix tablets were prepared by direct compression technique from the binary mixtures of SPDLA and microcrystalline cellulose, and theophylline was used as a model drug. The tablet matrices showed in vitro reproducible drug release profiles with a zero-order or diffusion-based kinetic depending on the SPDLA polymer grade used. Further release from the tablet matrices was dependent on the molecular weight of the SPDLA polymer applied. The drug release was the fastest with the lowest molecular weight SPDLA grade, and the drug release followed zero-order rate. With the higher molecular weight SPDLAs, more prolonged dissolution profiles for the matrix tablets (up to 8-10 h) were obtained. Furthermore, the prolonged drug release was independent of the pH of the dissolution media. In conclusion, SPDLAs are a novel type of drug carrier polymers applicable in oral controlled drug delivery systems. |
| Databáze: | OpenAIRE |
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