Regional fluorodeoxyglucose metabolism and instrumental activities of daily living across the Alzheimer's disease spectrum
| Autor: | Joseph J. Locascio, Reisa A. Sperling, Keith A. Johnson, Dorene M. Rentz, Gad A. Marshall, Marlie Philiossaint, Lesley C. Pepin, Kamolika Roy, J. Alex Becker, Natacha Lorius |
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| Rok vydání: | 2014 |
| Předmět: |
Gerontology
Male medicine.medical_specialty Activities of daily living Databases Factual Disease Audiology Brain mapping Article Alzheimer Disease Fluorodeoxyglucose F18 Surveys and Questionnaires mental disorders Activities of Daily Living medicine Dementia Humans Cognitive Dysfunction Longitudinal Studies Aged Fluorodeoxyglucose Aged 80 and over Brain Mapping medicine.diagnostic_test General Neuroscience Disease spectrum Brain General Medicine Middle Aged medicine.disease Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies Positron emission tomography Positron-Emission Tomography Disease Progression Female Geriatrics and Gerontology Alzheimer's disease Radiopharmaceuticals Psychology human activities medicine.drug Follow-Up Studies |
| Zdroj: | Journal of Alzheimer's disease : JAD. 42(1) |
| ISSN: | 1875-8908 |
| Popis: | Impairment in instrumental activities of daily living (IADL) begins as individuals with amnestic mild cognitive impairment (MCI) transition to Alzheimer's disease (AD) dementia. IADL impairment in AD dementia has been associated with inferior parietal, inferior temporal, and superior occipital hypometabolism using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET).To investigate the relationship between regional FDG metabolism and IADL in clinically normal (CN) elderly, MCI, and mild AD dementia subjects cross-sectionally and longitudinally.One hundred and four CN, 203 MCI, and 95 AD dementia subjects from the Alzheimer's Disease Neuroimaging Initiative underwent clinical assessments every 6 to 12 months for up to three years and baseline FDG PET. The subjective, informant-based Functional Activities Questionnaire was used to assess IADL. General linear models and mixed effects models were used, covarying for demographics, cognition, and behavior.The cross-sectional analysis revealed middle frontal and orbitofrontal hypometabolism were significantly associated with greater IADL impairment. Additionally, the interaction of diagnosis with posterior cingulate and with parahippocampal hypometabolism showed a greater decline in IADL performance as metabolism decreased for the AD dementia relative to the MCI group, and the MCI group relative to the CN group. The longitudinal analysis showed that baseline middle frontal and posterior cingulate hypometabolism were significantly associated with greater rate of increase in IADL impairment over time.These results suggest that regional synaptic dysfunction, including the Alzheimer-typical medial parietal and less typical frontal regions, relates to daily functioning decline at baseline and over time across the early AD spectrum. |
| Databáze: | OpenAIRE |
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