Is there an effect of thyroid autoimmunity on the outcomes of assisted reproduction?
| Autor: | Sureyya Saridas Demir, Ali Galip Zebitay, M. N. Sakar, Fatma Ferda Verit, M. Turfan, A. Unal, A. E. Atay, Beyhan Omer |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Infertility endocrine system medicine.medical_specialty Pregnancy Rate medicine.drug_class medicine.medical_treatment Oocyte Retrieval 030209 endocrinology & metabolism Chorionic Gonadotropin Iodide Peroxidase Dinoprostone Miscarriage 03 medical and health sciences Follicle-stimulating hormone 0302 clinical medicine Pregnancy medicine Humans Positive Pregnancy Test Euthyroid Prospective Studies Sperm Injections Intracytoplasmic Progesterone Autoantibodies Gynecology 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry Obstetrics and Gynecology Embryo Transfer medicine.disease Antral follicle Abortion Spontaneous Case-Control Studies Fertilization Female Gonadotropin business |
| Zdroj: | Journal of Obstetrics and Gynaecology. 36:213-217 |
| ISSN: | 1364-6893 0144-3615 |
| Popis: | We aimed to evaluate the role of thyroid autoantibodies (TAA) on the outcomes of intracytoplasmic sperm injection-embryo transfer (ICSI-ET). A prospective case-control study was conducted in the in vitro fertilisation (IVF) centre of Suleymaniye Maternity Training and Research Hospital, Istanbul, Turkey between July 2013 and March 2014. A total of 49 (19.52%) TAA-positive and 202 TAA-negative patients were enrolled. Demographic characteristics and laboratory parameters were recorded. All patients underwent ICSI-ET. Thirty-one TAA-positive patients (32 cycles) and 121 TAA-negative patients (126 cycles) completed the study. Mean female age, body mass index (BMI), type of infertility, duration of infertility, antral follicle count (AFC), anti-Mullerian hormone (AMH), basal follicle stimulating hormone (bFSH), luteinising hormone (bLH), and oestradiol (bE2), prolactin and thyroid hormone profiles, male age and aetiology of infertility of both groups were similar (p > 0.05). There was no significant difference between groups in terms of duration and dose of gonadotropin (Gn) therapy, day of human chorionic Gn (hCG) administration, serum E2 and progesterone levels, number of collected oocytes, ratio of fertilisation, number of available embryos, positive pregnancy test, biochemical pregnancy, clinical pregnancy, ratio of miscarriage and ongoing pregnancy (p > 0.05). In conclusion, we failed to demonstrate a significant role of TAA on the outcomes of ICSI-ET in euthyroid patients. Further studies with larger numbers of participants are required to clarify these data. |
| Databáze: | OpenAIRE |
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