Rat model of mild stenosis of the common bile duct
| Autor: | Gerardo B. Pisani, Emilio A. Rodriguez-Garay, Rut M. Agüero, Raul A. Trbojevich, Ricardo A. Viglianco, Abel Farroni |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Taurocholic Acid Cholagogues and Choleretics medicine.medical_specialty Time Factors Common Bile Duct Diseases medicine.medical_treatment Constriction Pathologic digestive system Gastroenterology Sulfobromophthalein Constriction Bile Acids and Salts Internal medicine Pressure medicine Animals Bile Rats Wistar Ligature Ligation Common bile duct Bile duct Chemistry Bilirubin General Medicine Bile duct proliferation Rats Disease Models Animal medicine.anatomical_structure Biliary tract Duct (anatomy) |
| Zdroj: | Research in Experimental Medicine. 196:105-116 |
| ISSN: | 1433-8580 0300-9130 |
| Popis: | Several techniques for developing incomplete obstruction of the common bile duct have been described but none of them properly represents a compression or constriction of the bile duct. In this study, a mild stenosis of the common bile duct was achieved in the rat by means of a double ligature including a cannula that could be easily slipped out of the ligatures. Sham-operated rats were used as controls. The studies, performed 7-10 days postoperatively, indicated that in ligated rats a duct constriction was produced, made evident by an increase of the biliary pressure, an upstream dilatation of the bile duct, an increase of the liver volume constituted by portal tracts, and ductular proliferation. Serum parameters were practically similar in ligated and control rats, except for a slight increase in serum bilirubin. Following intravenous injection of sodium taurocholate there were rapid increases of bile flow and bile salt output in both groups, but choleresis induced by sodium taurocholate was higher in ligated rats than in controls. The clearances of [14C]erythritol and [14C]sucrose suggested that ductular water contributing to bile flow and changes in biliary permeability were not involved in ligated rats. The limited repercussion of humoral effects and hepatic behaviour seen in ligated rats despite the morphological alterations induced make the mild stenosis of the bile duct a good model for the study of early stages of compression or constriction of the biliary tract. |
| Databáze: | OpenAIRE |
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