Agreement between self-reported and registry-based use of sleep medications and tranquilizers
| Autor: | Bente Oftedal, Gunn Marit Aasvang, Norun Hjertager Krog, Svetlana Skurtveit, Eva Skovlund, Per Nafstad, Jorunn Evandt, Per E. Schwarze |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Prescription Drugs Epidemiology Population Drug Prescriptions Sensitivity and Specificity 030226 pharmacology & pharmacy Prescription data 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Tranquilizing Agents Pharmacology (medical) Registries 030212 general & internal medicine Medical prescription education education.field_of_study Norway business.industry Pharmacoepidemiology Confidence interval Cross-Sectional Studies Sleep Aids Pharmaceutical Female Self Report Sleep (system call) business Kappa |
| Zdroj: | Pharmacoepidemiology and Drug Safety |
| ISSN: | 1053-8569 |
| Popis: | Purpose The purpose of the present study was to assess the agreement between self-reported use of sleep medications and tranquilizers and dispensed hypnotics and anxiolytics. Methods Self-reported medication use was obtained from the population-based survey Health and Environment in Oslo (HELMILO) (2009-2010) (n = 13 019). Data on dispensed hypnotics and anxiolytics were obtained from the Norwegian Prescription Database (NorPD). As measures of validity, we calculated sensitivity and specificity using both self-reports and prescription records as the reference standard. Furthermore, we calculated Cohen's kappa. Current self-reported medication use was compared with prescription data in time windows of both 100 and 200 days preceding questionnaire completion. Results The highest sensitivity was observed for current sleep medication use in the 100-day time window (sensitivity = 0.76, 95% confidence interval [CI]: 0.74, 0.79) when using prescription records as the reference standard. Sensitivity was generally lower for tranquilizers compared with sleep medications. Cohen's kappa showed the highest agreement for the 200-day time window with substantial agreement for sleep medications (kappa = 0.64; 95% CI: 0.62, 0.67) and moderate agreement for tranquilizers (kappa = 0.45; 95% CI: 0.41, 0.48). Conclusions The present study suggests moderate to substantial agreement between self-reported use of sleep medications and tranquilizers and dispensed drugs in a general adult population. The magnitude of agreement varied according to drug category and time window. Since self-reported and registry-based use of these drug classes does not match each other accurately, limitations of each data source should be considered when such medications are applied as the exposure or outcome in epidemiologic studies. |
| Databáze: | OpenAIRE |
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