Cold-Burst Method for Nanoparticle Formation with Natural Triglyceride Oils
| Autor: | Slavka Tcholakova, Desislava Glushkova, Diana Cholakova, Nikolai D. Denkov |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
FOS: Physical sciences 02 engineering and technology Condensed Matter - Soft Condensed Matter 010402 general chemistry 01 natural sciences Micelle Contact angle Surface tension Surface-Active Agents Pulmonary surfactant Electrochemistry Surface Tension General Materials Science Triglycerides Spectroscopy Aqueous solution Drop (liquid) Water Surfaces and Interfaces 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Chemical engineering Soft Condensed Matter (cond-mat.soft) Nanoparticles Particle Palm kernel oil 0210 nano-technology Oils |
| Zdroj: | Langmuir |
| ISSN: | 1520-5827 0743-7463 |
| DOI: | 10.1021/acs.langmuir.0c02967 |
| Popis: | The preparation of nanoemulsions of triglyceride oils in water usually requires high mechanical energy and sophisticated equipment. Recently, we showed that α-to-β (viz., gel-to-crystal) phase transition, observed with most lipid substances (triglycerides, diglycerides, phospholipids, alkanes, etc.), may cause spontaneous disintegration of microparticles of these lipids, dispersed in aqueous solutions of appropriate surfactants, into nanometer particles/drops using a simple cooling/heating cycle of the lipid dispersion (Cholakova et al. ACS Nano2020, 14, 8594). In the current study, we show that this "cold-burst process" is observed also with natural oils of high practical interest, including coconut oil, palm kernel oil, and cocoa butter. Mean drop diameters of ca. 50-100 nm were achieved with some of the studied oils. From the results of dedicated model experiments, we conclude that intensive nanofragmentation is observed when the following requirements are met: (1) The three-phase contact angle at the solid lipid-water-air interface is below ca. 30 degrees. (2) The equilibrium surface tension of the surfactant solution is below ca. 30 mN/m, and the dynamic surface tension decreases rapidly. (3) The surfactant solution contains nonspherical surfactant micelles, e.g., ellipsoidal micelles or bigger supramolecular aggregates. (4) The three-phase contact angle measured at the contact line (frozen oil-surfactant solution-melted oil) is also relatively low. The mechanism(s) of the particle bursting process is revealed, and on this basis, the role of all of these factors is clarified and discussed. We explain all main effects observed experimentally and define guiding principles for optimization of the cold-burst process in various, practically relevant lipid-surfactant systems. |
| Databáze: | OpenAIRE |
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