Levosimendan in Acute and Advanced Heart Failure : An Appraisal of the Clinical Database and Evaluation of Its Therapeutic Applications

Autor: Gabriella Malfatto, Matti Kivikko, Veli-Pekka Harjola, Johann Altenberger, Finn Gustafsson, Piero Pollesello, Kristjan Karason, Zoltán Papp, Detlef Kindgen-Milles, Carsten Tschöpe, John Parissis, Gerhard Pölzl
Přispěvatelé: HUS Emergency Medicine and Services, Department of Medicine, Clinicum, Kardiologian yksikkö
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Inotrope
Databases
Factual
Vasodilator Agents
Hemodynamics
inotropes
030204 cardiovascular system & hematology
INTRAVENOUS LEVOSIMENDAN
inodilators
law.invention
Heart Failure/diagnosis
0302 clinical medicine
Randomized controlled trial
Quality of life
law
Risk Factors
030212 general & internal medicine
Elméleti orvostudományok
Orvostudományok
EUROPEAN-SOCIETY
3. Good health
Vasodilation
Vasodilator Agents/adverse effects
Treatment Outcome
317 Pharmacy
Acute Disease
Cardiology
Myocardial Contraction/drug effects
Cardiology and Cardiovascular Medicine
medicine.drug
medicine.medical_specialty
Cardiotonic Agents
acute heart failure
Clinical Decision-Making
MEDLINE
Simendan/adverse effects
DOBUTAMINE
Article
03 medical and health sciences
levosimendan
INTERMITTENT
Internal medicine
medicine
Humans
Intensive care medicine
Simendan
METAANALYSIS
Pharmacology
Heart Failure
business.industry
Patient Selection
MORTALITY
Vasodilation/drug effects
Hydrazones
INFUSIONS
Cardiotonic Agents/adverse effects
Levosimendan
Recovery of Function
Congresses as Topic
medicine.disease
EFFICACY
Drugs in the Pipeline
Myocardial Contraction
advanced heart failure
IMPROVES RENAL-FUNCTION
RANDOMIZED-TRIAL
Heart failure
3121 General medicine
internal medicine and other clinical medicine
Chronic Disease
Dobutamine
business
Zdroj: Journal of Cardiovascular Pharmacology
Altenberger, J, Gustafsson, F, Harjola, V-P, Karason, K, Kindgen-Milles, D, Kivikko, M, Malfatto, G, Papp, Z, Parissis, J, Pollesello, P, Pölzl, G & Tschöpe, C 2018, ' Levosimendan in Acute and Advanced Heart Failure : An Appraisal of the Clinical Database and Evaluation of Its Therapeutic Applications ', Journal of Cardiovascular Pharmacology, vol. 71, no. 3, pp. 129-136 . https://doi.org/10.1097/FJC.0000000000000533
DOI: 10.1097/FJC.0000000000000533
Popis: The use of inotropes for correcting hemodynamic dysfunction in patients with congestive heart failure has been described over many decades. However, negative or insufficient data have been collected regarding the effects of cardiac glycosides, catecholamines, and phosphodiesterase inhibitors on quality of life and survival. More recently, the calcium sensitizer and potassium channel-opener levosimendan has been proposed as a safer inodilator than traditional agents in some heart failure settings, such as advanced heart failure. At the 2017 annual congress of the Heart Failure Association of the European Society of Cardiology (Paris, April 30-May 2), a series of tutorials delivered by lecturers from 8 European countries examined how to use levosimendan safely and effectively in acute and advanced heart failure. The proceedings of those tutorials have been collated in this review to provide an expert perspective on the optimized use of levosimendan in those settings.
Databáze: OpenAIRE
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