The relationship between stress and vitiligo: Evaluating perceived stress and electronic medical record data

Autor: Levi Barse, Nicola Lancki, Steven W. Henning, Dinesh Jaishankar, Herbert L. Mathews, I. Caroline Le Poole, Ron Price, Kirsten Webb, Emilia R. Dellacecca, Linda Witek Janusek
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Questionnaires
T-Lymphocytes
Perceived Stress Scale
Social Sciences
Vitiligo
Disease
Epithelium
Heat Shock Response
030207 dermatology & venereal diseases
0302 clinical medicine
Drug Metabolism
Animal Cells
Surveys and Questionnaires
Stress (linguistics)
Medicine and Health Sciences
Psychology
Young adult
Child
skin and connective tissue diseases
Cellular Stress Responses
Metabolic Syndrome
Multidisciplinary
integumentary system
Electronic medical record
Middle Aged
Research Design
Cell Processes
Child
Preschool
Melanocytes
Medicine
Female
Cellular Types
Anatomy
Research Article
Adult
medicine.medical_specialty
Adolescent
Patients
Science
Immunology
Psychological Stress
Research and Analysis Methods
Autoimmune Diseases
03 medical and health sciences
Young Adult
Stress
Physiological
Mental Health and Psychiatry
medicine
Humans
Pharmacokinetics
Chromatophores
Aged
Pharmacology
Survey Research
business.industry
Infant
Newborn
Infant
Biology and Life Sciences
Epithelial Cells
Cell Biology
medicine.disease
Dermatology
Health Care
030104 developmental biology
Biological Tissue
Skin color
Metabolic Disorders
Clinical Immunology
Metabolic syndrome
Clinical Medicine
business
Heat-Shock Response
Stress
Psychological
Zdroj: PLoS ONE, Vol 15, Iss 1, p e0227909 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: Vitiligo is a T-cell mediated skin disorder characterized by progressive loss of skin color. In individuals genetically predisposed to the disease, various triggers contribute to the initiation of vitiligo. Precipitating factors can stress the skin, leading to T-cell activation and recruitment. Though hereditary factors are implicated in the pathogenesis of vitiligo, it is unknown whether precipitating, stressful events play a role in vitiligo. To understand this, we utilized a validated perceived stress scale (PSS) to measure this parameter in vitiligo patients compared to persons without vitiligo. Additionally, we probed a clinical database, using a knowledge linking software called ROCKET, to gauge stress-related conditions in the vitiligo patient population. From a pool of patients in an existing database, a hundred individuals with vitiligo and twenty-five age- and sex-matched comparison group of individuals without vitiligo completed an online survey to quantify their levels of perceived stress. In parallel, patients described specifics of their disease condition, including the affected body sites, the extent, duration and activity of their vitiligo. Perceived stress was significantly higher among vitiligo individuals compared to those without vitiligo. ROCKET analyses suggested signs of metabolic-related disease (i.e., 'stress') preceding vitiligo development. No correlation was found between perceived stress and the stage or the extent of disease, suggesting that elevated stress may not be a consequence of pigment loss alone. The data provide further support for stress as a precipitating factor in vitiligo development.
Databáze: OpenAIRE
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