Two rare developmental defects of the lower limbs with confirmation of the Lewin and Opitz hypothesis on the fibular and tibial developmental fields
| Autor: | Giovanni Neri, Salvatore Ardito, Denis Viljoen, Renata Rizzo, Lorenzo Pavone, Peter Beighton, Gianfranco Longo |
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| Předmět: |
musculoskeletal diseases
Foot Deformities Congenital Left femur medicine Humans Abnormalities Multiple Femur Tibia Syndactyly Fibula Genetics (clinical) Leg Bone Development Foot business.industry Partial duplication Preaxial polydactyly Infant Anatomy musculoskeletal system medicine.disease Hypoplasia Female business |
| Zdroj: | Scopus-Elsevier |
| Popis: | We report on two unrelated patients with malformations of the lower limbs. One had a unilateral apparent doubling of the volume of the femur with distal bifurcation, shortness of the tibiae, absence of fibulae, and lateral ray deficiencies of both feet. The other had a partial duplication of the distal left femur, hypoplasia and proximal dislocation of the ipsilateral tibia, syndactyly of the right 1st and 2nd toes, and preaxial polydactyly of the left foot. This report supports the hypothesis of Lewin and Opitz on the presence of two distinct fields of development: the fibular and the tibial. |
| Databáze: | OpenAIRE |
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