Opening Pandora’s box: Mechanisms of Mycobacterium tuberculosis resuscitation
| Autor: | Deepak Kaushal, Ashley V. Veatch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Resuscitation 030106 microbiology Antitubercular Agents Disease Microbiology Article Mycobacterium tuberculosis 03 medical and health sciences Bacterial Proteins Latent Tuberculosis Virology Global health medicine Animals Humans Tuberculosis biology Latent tuberculosis Active tuberculosis biology.organism_classification medicine.disease 030104 developmental biology Infectious Diseases Immunology Models Animal |
| Popis: | Mycobacterium tuberculosis (Mtb) infection characteristically causes an asymptomatic infection. While this latent tuberculosis infection (LTBI) is not contagious, reactivation to active tuberculosis disease (TB) causes the patient to become infectious. A vaccine has existed for TB for a century while drug treatments have been available for over 70 years; despite this, TB remains a major global health crisis. Understanding factors which allow the bacillus to control response to host stress and mechanisms leading latency are critical for persistence. Similarly, molecular switches which respond to reactivation are important. Recently, research in the field has sought to focus on reactivation, employing system-wide approaches and animal models. Here, we describe the current work that has been done to elucidate the mechanisms of reactivation and stop reactivation in its tracks. |
| Databáze: | OpenAIRE |
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