Infection and Immunization of Cats with the Kawakami-Theilen Strain of Feline Leukemia Virus
| Autor: | Andre H. Phelps, V. M. Larson, Ronald A. Salerno, Maurice R. Hilleman |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
viruses Guinea Pigs Viremia Biology Antibodies Viral Feline leukemia virus General Biochemistry Genetics and Molecular Biology Virus Pregnancy hemic and lymphatic diseases medicine Animals Maternal-Fetal Exchange Leukemia Experimental CATS Strain (chemistry) Leukemia Virus Feline Vaccination Immunization Passive virus diseases Viral Vaccines medicine.disease biology.organism_classification Virology Tumor Virus Infections Leukemia Animals Newborn Immunization Cats Female |
| Zdroj: | Experimental Biology and Medicine. 160:18-23 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-160-40379 |
| Popis: | SummaryInjection of high doses of KT-FeLV feline leukemia virus produced both viremia and leukemia in a portion of 1- to 2-day-old kittens but not in 17- to 24-week-old animals. Contact of susceptible cats with infected cagemates did not result in viremia or disease. Development of cytotoxic antibody was coordinated with protection against viremia and disease in kittens challenged with FeL V virus. The rapid evolution of resistance to KT-FeLV virus precluded the development of a practical means for conventional vaccination and challenge experiments in cats. Killed vaccine given to pregnant queens did, however, afford protection against FeLV virus on challenge in the progeny. |
| Databáze: | OpenAIRE |
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