Nonalcoholic fatty liver disease (NAFLD) – a new factor that interplays between inflammation, malnutrition, and atherosclerosis in elderly hemodialysis patients
| Autor: | Branka Sladoje-Martinović, Vesna Lukenda, Lidija Orlić, Sanjin Rački, Ivana Mikolašević, Sandra Milić |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
cardiovascular risk
Male medicine.medical_specialty Croatia Endpoint Determination medicine.medical_treatment Population serum albumin Gastroenterology high-sensitivity C-reactive protein (hs-CRP) Non-alcoholic Fatty Liver Disease Renal Dialysis Risk Factors Internal medicine Nonalcoholic fatty liver disease medicine Humans Prospective Studies education BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine Dialysis Original Research Aged BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina Aged 80 and over Inflammation education.field_of_study business.industry Fatty liver Malnutrition General Medicine medicine.disease Atherosclerosis hemodialysis elderly malnutrition nonalcoholic fatty liver disease Surgery Transplantation Survival Rate C-Reactive Protein Clinical Interventions in Aging Kidney Failure Chronic Female Hemodialysis Geriatrics and Gerontology Metabolic syndrome business Dyslipidemia |
| Zdroj: | Clinical Interventions in Aging Volume 9 |
| ISSN: | 1178-1998 1176-9092 |
| Popis: | Ivana Mikolasevic,1 Vesna Lukenda,2 Sanjin Racki,1 Sandra Milic,3 Branka Sladoje-Martinovic,1 Lidija Orlic1 1Department of Nephrology, Dialysis and Transplantation, Rijeka University Hospital Center, Rijeka, Croatia; 2Department of Internal Medicine, Dr Josip Bencevic General Hospital, Slavonski Brod, Croatia; 3Department of Gastroenterology, Rijeka University Hospital Center, Rijeka, Croatia Background/aim: In the past decade, in most regions of the world, an increasing number of adults aged 65 years and older were started on renal replacement therapy each year. In contrast to the general population for whom overnutrition or obesity is associated with increased cardiovascular risk, for patients who are maintained on hemodialysis (HD), malnutrition and malnutrition-inflammation complex syndrome are associated with poor outcome. In recent years, nonalcoholic fatty liver disease (NAFLD) has been considered to be the liver manifestation of metabolic syndrome, and the development of NAFLD is strongly associated with all components of metabolic syndrome (arterial hypertension, dyslipidemia, obesity, and diabetes mellitus type 2) in the general population. The primary end point of this study was to determine the patient’s survival in relation to nutritional and inflammatory state and the presence or absence of NAFLD. The secondary end point of this analysis was the association among NAFLD and various clinical and laboratory data, with the nutritional and inflammatory state of our elderly HD patients. Methods: Using a single-center, prospective, cohort study design, we followed the progress of 76 patients who were ≥65 years and treated with chronic HD for at least 6 months, at the Department of Nephrology, Dialysis and Transplantation. All patients were followed for a minimum of 18 months or until death. Survival was defined as the time from study initiation to death (or end of study, if still alive).Results: The main findings of our study were a remarkable positive correlation between NAFLD and high-sensitivity C-reactive protein (hs-CRP) (r=0.659; P |
| Databáze: | OpenAIRE |
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