Synthesis, Surface‐Active Properties, and Anthelmintic Activities of New Cationic Gemini Surfactants Against the Gastrointestinal Nematode, Heligmosomoides polygyrus bakeri , In Vitro
| Autor: | Amilcar Bassi, Claudio Giudici, Victoria Guadalupe Sánchez, Marcelo Cesar Murguia |
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| Rok vydání: | 2012 |
| Předmět: |
SURFACE-ACTIVE PROPERTIES
biology Chemistry Otras Ciencias Químicas Ciencias Veterinarias General Chemical Engineering Ciencias Químicas Cationic polymerization Nanotechnology biology.organism_classification Surfaces Coatings and Films Microbiology CIENCIAS AGRÍCOLAS CATIONIC DIMERIC COMPOUNDS ANTHELMINTIC ACTIVITY medicine Heligmosomoides polygyrus Anthelmintic Gastrointestinal nematode GEMINI SURFACTANTS Physical and Theoretical Chemistry CIENCIAS NATURALES Y EXACTAS medicine.drug |
| Zdroj: | Journal of Surfactants and Detergents. 15:463-470 |
| ISSN: | 1558-9293 1097-3958 |
| DOI: | 10.1007/s11743-012-1337-0 |
| Popis: | A novel series of cationic dimeric surfactants was prepared involving the ketalization reaction, Williamson etherification, and regioselective oxirane ring opening with tertiary alkyl amines. The synthesized compounds were obtained in high purity by a simple purification procedure using column chromatography. The critical micelle concentration (CMC), effectiveness of surface tension reduction (γCMC), surface excess concentration (Γ), and area per molecule at the interface (A) were determined and values indicate that the cationic series is characterized by good surface-active and self-aggregation properties. For the first time, we reported the anthelmintic activities against the rodent gastrointestinal nematode Heligmosomoides polygyrus bakeri, in vitro for cationic gemini compounds. In the series of five tested cationic compounds (4a-e), three of them (4a, 4b and 4d) were shown to have an excellent anthelmintic activity in vitro at different concentrations. The anthelmintic activity was found to be dependent on the type of cationic compound, concentration and incubation time. The cationic di-C12 (4a) derivate of the series was the best anthelmintic agent, its use was optimal at a minimum concentration of 50 ppm and with 60 min of incubation. Fil: Sánchez, Victoria Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina Fil: Giudici, Claudio. Universidad Nacional de Rosario. Facultad de Ciencias Veterinarias; Argentina Fil: Bassi, Amilcar. Universidad Nacional de Rosario. Facultad de Ciencias Veterinarias; Argentina Fil: Murguia, Marcelo Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina |
| Databáze: | OpenAIRE |
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